上海交通大学学报（医学版）

上海交通大学学报（医学版）

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子宫内膜癌相关基因的研究进展

刘 杰，陶敏芳   

  1. 上海交通大学附属第六人民医院妇产科， 上海 200233
  • 出版日期:2014-03-28 发布日期:2014-04-02
  • 通讯作者: 陶敏芳, 电子信箱: taomf@126.com。
  • 作者简介:刘 杰（1989—）， 男， 硕士生; 电子信箱: liujie32jat@126.com。
  • 基金资助:

    上海市科委基金（11411950103）

Research progress of related genes of endometrial cancer

LIU Jie, TAO Min-fang   

  1. Department of Obstetrics and Gynecology, the Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2014-03-28 Published:2014-04-02
  • Supported by:

    Foundation of Science and Technology Commission of Shanghai Municipality, 11411950103

PDF (PC)

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摘要：

子宫内膜癌是一种常见的妇科恶性肿瘤，其发病受基因与环境因素共同影响。基因改变是子宫内膜癌发病的重要因素，原癌基因、抑癌基因、雌激素代谢相关基因及雌、孕激素受体基因的突变和多态性均会增加子宫内膜癌的发病风险。探讨相关基因对子宫内膜癌的影响，有助于对子宫内膜癌的发病进行预测，并对女性进行相关的健康指导。目前，已有数个基因被发现与子宫内膜癌发病有关，该文就子宫内膜癌相关基因的研究进展进行综述。

关键词: 子宫内膜癌, 基因, 单核苷酸基因多态性

Abstract:

Endometrial cancer is a common gynecological malignant tumor which is induced both by genes and environment. The gene effects are prominent. Protooncogenes, tumor suppressor genes, estrogen metabolism genes, and estrogen and progesterone receptor gene mutations and polymorphisms could increase the risk of endometrial cancer. Exploration of gene factors of endometrial cancer helps predicting the onset of the endometrial cancer and may provide appropriate health guidance for women. Currently several genes have been found to be associated with endometrial cancer. The research progress of relevant genes of endometrial cancer is reviewed in this paper.

Key words: endometrial cancer, gene, single nucleotide polymorphisms