上海交通大学学报（医学版）

上海交通大学学报（医学版）

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低氧诱导因子在急性肾损伤中作用的研究进展

文 丹1, 张 文2   

  1. 1.上海交通大学 医学院, 上海 200025； 2.上海交通大学 医学院附属瑞金医院肾内科, 上海 200025
  • 出版日期:2014-03-28 发布日期:2014-04-02
  • 作者简介:文 丹（1990—）， 女， 硕士生; 电子信箱: specialwda@163.com。
  • 基金资助:

    上海市科委基础研究重点项目（11JC1407900,11JC1407901）；上海市科委“创新行动计划”基础研究领域重大项目（12DJ1400303）

Advances of role of hypoxia inducible factor in acute kidney injury

WEN Dan1, ZHANG Wen2   

  1. 1.Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2.Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2014-03-28 Published:2014-04-02
  • Supported by:

    Fundamental Research Key Project of Science and Technology Commission of Shanghai Municipality, 11JC1407900, 11JC1407901; “Innovation Action Plan”, Fundamental Research Major Project of Science and Technology Commission of Shanghai Municipality, 12DJ1400303

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摘要：

急性肾损伤(AKI)是指以急性肾功能减退为特征的一组临床综合征，常见病因为休克、手术和脓毒血症等。低氧诱导因子(HIF)是一种转录因子，在机体多种低氧适应性反应调控中发挥主要的开关作用。文章综述了HIF的结构功能、AKI的流行病学及病生机制、HIF在AKI中的主要作用及研究进展。

关键词: 低氧诱导因子, 急性肾损伤, 缺氧

Abstract:

Acute kidney injury (AKI) is a set of clinical syndromes characterized by acute renal function impairment. Shock, surgery, and sepsis are major pathogeneses of AKI. Hypoxia inducible factor(HIF) is a kind of transcription factor which acts as a main switch in the regulation of multiple hypoxia adaptive responses of the body. The stucture and function of HIF, and the epidemiology and pathophysiology of AKI are reviewed in this paper, and the research progress of the main role that HIF plays in AKI is analyzed.

Key words: hypoxia inducible factor, acute kidney injury, hypoxia