上海交通大学学报（医学版）

上海交通大学学报（医学版）

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神经系统疾病中应用诱导多能干细胞的研究进展

马辰凯，马 杰   

  1. 上海交通大学医学院附属新华医院小儿神经外科, 上海 200092
  • 出版日期:2014-08-28 发布日期:2014-09-02
  • 通讯作者: 马 杰, 电子信箱: majie365@hotmail.com。
  • 基金资助:

    国家重大科学研究计划（2010CB945203）；国家自然科学基金面上项目（81271382）

Advances in application of induced pluripotent stem cells in neurological diseases

MA Chen-kai, MA Jie   

  1. Department of Paediatric Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2014-08-28 Published:2014-09-02
  • Supported by:

    National Major Science Research Project，2010CB945203；  National Natural Science Foundation of China, 81271382

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摘要：

诱导多能干细胞(iPSCs)是将已分化完全的体细胞进行重编程，使之成为多能干细胞。现已有多项关键新技术的实施大大提升了iPSCs的转染效率和临床安全性。目前将iPSCs定向分化成的神经前体细胞、胶质细胞和神经元样细胞移植治疗各种神经系统疾病，展现出非常良好的前景。同时，利用iPSCs技术能在体外构建相关疾病模型，并进行药物筛选。本文就目前iPSCs在神经系统疾病中的应用作一综述。

关键词: 诱导多能干细胞, 神经系统疾病, 药物筛选

Abstract:

Induced pluripotent stem cells (iPSCs) technology reprograms differentiated somatic cells and induces them to pluripotent stem cells. At present many novel technologies have improved the transfection efficiency and clinical safety of iPSCs. Neural precursor cells, glial cells, and neuron-like cells derived from iPSCs can be transplanted to treat neurological diseases and the results show good prospects. The iPSCs technology can also be used to establish models of relevant diseases in vitro and screen drugs. This paper reviews the applications of iPSCs in neurological diseases.

Key words: induced pluripotent stem cells, neurological diseases, drugs profiling