上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 综述 • 上一篇    

血清肿瘤标志物在胃癌诊疗中的应用

华子辰，朱正伦，朱正纲   

  1. 上海交通大学 医学院附属瑞金医院普外科， 上海 200025
  • 出版日期:2014-09-28 发布日期:2014-09-26
  • 通讯作者: 朱正纲, 电子信箱: zzg1954@hotmail.com。
  • 作者简介:华子辰（1988—）， 男， 博士生; 电子信箱: huazichen0801@hotmail.com。
  • 基金资助:

    上海高校选拔培养优秀青年教师科研专项基金（ZZjdyx12021）

Application of serum tumor markers for diagnosis and treatment of gastric cancer

HUA Zi-chen, ZHU Zheng-lun, ZHU Zheng-gang   

  1. Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2014-09-28 Published:2014-09-26
  • Supported by:

    Special Fund for Shanghai University Scientific Selection and Cultivation for Outstanding Young Teachers, ZZjdyx12021

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摘要：

胃癌发病率高，预后差，是威胁人类生命的第二大恶性肿瘤。胃癌的预后与肿瘤的分期及复发、转移密切相关，改善胃癌的预后有赖于早期诊断、早期治疗以及术后合理的监测。血清肿瘤标志物（TM）的检测由于便捷、可重复性高，对胃癌的早期诊断及术后监测有很高的应用价值。该文回顾了胃癌传统TM糖类抗原125（CA125）、CA199、CA724和癌胚抗原(CEA)的特点，介绍了数种新型TM，如PG、MG7、VEGF和HER2等的研究进展，就TM在胃癌临床诊疗中的应用价值及发展前景作一综述。

关键词: 胃癌, 肿瘤标志物, 诊断, 治疗, 预后

Abstract:

The gastric cancer is the second most malignant tumor that threats human lives due to high incidence and poor prognosis. The prognosis of gastric cancer is closely related to staging, recurrence, and metastasis. The improvement of its prognosis relies on early diagnosis, early treatment, and reasonable postoperative monitoring. Serum tumor markers (TM) are valuable for early diagnosis and postoperative monitoring because their detection is convenient and highly repetitive. This paper introduces features of traditional serum TMs of gastric cancer, including CA125, CA199, CA724, and CEA; presents research progresses of several new TMs, such as PG, MG7, VEGF and HER2; and reviews the practical value and prospects of TM for the diagnosis and treatment of gastric cancer.

Key words: gastric cancer, tumor markers, diagnosis, treatment, prognosis