上海交通大学学报（医学版）

上海交通大学学报（医学版）

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MicroRNA——急性肺损伤的新型调控分子

曹永梅，李颖川   

  1. 上海交通大学附属第六人民医院麻醉科， 上海 200233
  • 出版日期:2014-10-28 发布日期:2014-10-28
  • 作者简介:曹永梅（1988—）， 女， 硕士生; 电子信箱: caoym1117@sjtu.edu.cn。
  • 基金资助:

    国家自然科学基金（81272145）；上海市卫生局基金（2009089）

MicroRNA: a novel regulatory molecule of acute lung injury

CAO Yong-mei, LI Ying-chuan   

  1. Department of Anesthesiology, the Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2014-10-28 Published:2014-10-28
  • Supported by:

    National Natural Science Foundation of China，81272145； Foundation of Shanghai Municipal Health Bureau，2009089

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摘要：

急性肺损伤（ALI）是以严重肺部炎症为特征的常见的复杂性疾病。微小RNA （miRNA）作为一类新型的基因调控分子，在许多疾病包括ALI的病理过程中发挥着至关重要的作用。在肺损伤和修复过程中，特定种类的miRNA 异常表达，并通过影响其靶基因的表达调控炎症通路和免疫反应。因此，miNRA可作为ALI的生物学标志物。文章就miNRA在ALI中的作用进行综述。

关键词: 微小RNA, 急性肺损伤, 炎症, 免疫反应

Abstract:

Acute lung injury (ALI) is a common and complex disease characterized by severe pulmonary inflammation. As a new type of gene regulator, microRNA (miRNA) plays vital roles in a wide range of human disorders and diseases, including ALI. During the process of lung injury and repair, certain kinds of miRNA express abnormally and can modulate inflammation pathways as well as immune response by affecting expressions of target genes. Therefore, miRNA can serve as biological markers for ALI. This paper reviews the effects of miRNA on ALI.

Key words: microRNA, acute lung injury, inflammation, immune response