上海交通大学学报（医学版）

上海交通大学学报（医学版）

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Sirtuins在慢性肾脏疾病发生、发展中的作用

张琳1，贺明2   

  1. 上海交通大学 医学院 1.生物化学与分子细胞生物学系， 2.细胞分化与凋亡教育部重点实验室， 病理生理学教研室， 上海 200025
  • 出版日期:2015-04-28 发布日期:2015-04-29
  • 通讯作者: 贺明, 电子信箱: heming@shsmu.edu.cn。
  • 作者简介:张琳（1982—）， 女， 实验师， 硕士; 电子信箱: linzhang3300@gmail.com。
  • 基金资助:

    国家自然科学基金（81470841，81170505）

Roles of Sirtuins in occurrence and development of chronic kidney disease

ZHANG Lin1, HE Ming2   

  1. 1.Department of Biochemistry and Molecular Cell Biology, 2.Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2015-04-28 Published:2015-04-29
  • Supported by:

    National Natural Science Foundation of China， 81470841， 81170505

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摘要：

慢性肾脏疾病的发病率呈明显上升趋势，而衰老是慢性肾脏疾病发病的一个危险因素。Sirtuins蛋白家族是一类高度保守的NAD+依赖性去乙酰化酶，在热量限制、寿命调控以及多种代谢疾病中起重要作用。位于细胞核中的 SIRT1和 SIRT6 可通过对组蛋白和转录调控因子去乙酰化调控基因表达，从而抑制慢性肾脏疾病患者肾脏中的细胞凋亡、炎症和纤维化，同时也可调节细胞应激反应、脂质代谢、自噬、血压和钠平衡。而位于线粒体的 SIRT3 可调节多种线粒体内酶的活性，从而参与慢性肾脏疾病的发生、发展。本文就Sirtuins蛋白在慢性肾脏疾病中的作用及机制的研究进展进行综述。

关键词: 慢性肾脏疾病, Sirtuins, 去乙酰化, 衰老

Abstract:

The incidence of chronic kidney disease has been increasing worldwide over recent years. Aging is a risk factor of the occurrence and development of chronic kidney disease. Sirtuin (silent mating type information regulation 2 homolog) is a conserved family of proteins with NAD+-dependent deacetylase. Sirtuins play vital roles in caloric restriction, longevity, and various metabolic diseases. The activation of nuclear SIRT1 and SIRT6 may induce gene silencing through deacetylation, then lead to reduction of apoptosis, inhibition of inflammation and fibrosis induced by chronic kidney disease. Meanwhile, SIRT1 may regulate stress responses, glucose and lipid metabolism, induction of autophagy, blood pressure, and sodium handling. SIRT3 locates in the mitochondria and regulates the activity of mitochondrial enzymes to involve in the pathogenesis of chronic kidney disease. This paper reviews the latest research progresses of the roles of Sirtuins in the occurrence and development of chronic kidney disease.

Key words: chronic kidney disease, Sirtuins, deacetylation, aging