上海交通大学学报（医学版）

上海交通大学学报（医学版）

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无绿藻病研究新进展

王影1,2，刘锦燕2，史册1，李文静1，项明洁2,1   

  1. 上海交通大学 医学院附属瑞金医院 1.检验科， 上海 200025； 2.卢湾分院放免检验科， 上海 200020
  • 出版日期:2015-05-28 发布日期:2015-06-04
  • 通讯作者: 项明洁, 电子信箱: mjxiang123456@126.com。
  • 作者简介:王影（1989—）， 女， 硕士生; 电子信箱: sjdwangying@163.com。
  • 基金资助:

    上海市医学重点专科配套课题(ZK2012A21)；黄浦区卫生局项目(2012-HGG-44)

Advances of protothecosis

WANG Ying1,2, LIU Jin-yan2, SHI Ce1, LI Wen-jing1, XIANG Ming-jie2,1   

  1. 1.Department of Clinical Microbiology Laboratory, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2.Radioimmunology and Clinical Laboratory, Luwan Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
  • Online:2015-05-28 Published:2015-06-04
  • Supported by:
    Shanghai Key Specialty of Medicine Supporting Project, ZK2012A21; Huangpu District Health Bureau Foundation, 2012-HGG-44

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摘要：

无绿藻病是由条件致病菌无绿藻引起的一种较为罕见的疾病。近年来，随着免疫缺陷患者的增多，无绿藻病的发生率有上升趋势。无绿藻病以皮肤型多见，也可表现为鹰嘴滑囊及纤维组织感染或系统性感染。由于已报道的无绿藻病例数有限，其发病机制还不是很清楚，临床表现缺乏特异性，微生物学检查易被误认为酵母菌而漏检。为了提高对无绿藻病的认识，该文分析总结国内外已报道的无绿藻病，就其病因、发病机制、临床表现、诊断特征、治疗及预后等作一综述。

关键词: 无绿藻病, 发病机制, 小型无绿藻, 中型无绿藻

Abstract:

Protothecosis is a rare infection caused by members of genus Prototheca, which are opportunistic pathogens. Given the increasing number of immunocompromised individuals throughout the world, the incidence of protothecosis keeps increasing. The most common clinical manifestation of protothecosis is cutaneous protothecosis, as well as olecranon bursitis, fibrous tissue infection, and systemic infection. Because of the limited cases of protothecosis, the pathogenesis of protothecosis is largely unknown; the manifestations are lack of specificity; and it is commonly misidentified as the yeast in clinical laboratory. In order to improve the understanding of protothecosis, this paper reviews reported cases of protothecosis at home and abroad, and summarizes its etiology, pathogenesis, clinical manifestation, diagnostic features, treatment, and prognosis.

Key words: protothecosis, pathogenesis, Prototheca wickerhamii, Prototheca zopfii