上海交通大学学报（医学版）

上海交通大学学报（医学版）

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选择性剪接调控的研究进展

徐谷峰1, 周承亮1, 黄荷凤2   

  1. 1.浙江大学 教育部生殖遗传重点实验室， 杭州 310058； 2.上海交通大学 医学院附属国际和平妇幼保健院生殖内分泌科， 上海 200030
  • 出版日期:2015-05-28 发布日期:2015-06-04
  • 通讯作者: 黄荷凤, 电子信箱: huanghefg@hotmail.com。
  • 作者简介:徐谷峰（1986—）， 男， 博士生; 电子信箱: xugufeng@sina.com。

Research progresses of regulation of alternative splicing

XU Gu-feng1, ZHOU Cheng-liang1, HUANG He-feng2   

  1. 1.Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou 310058, China; 2.Department of Reproductive Endocrinology, International Peace Maternal and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2015-05-28 Published:2015-06-04

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摘要：

选择性剪接是剪除未成熟mRNA中的内含子、保留外显子后生成成熟mRNA的过程。在各类疾病发生和发展过程中，异常的选择性剪接起着重要作用。该文就选择性剪接的发生与调控机制、功能及其与疾病关系的研究进展进行综述。

关键词: 选择性剪接, 剪接因子, 疾病发生, RNA, 异构体

Abstract:

Alternative splicing is an essential process to form mature mRNA by splicing introns from immature mRNA while keeping extrons. The abnormal alternative splicing plays an important role in the incidence and development of various diseases. This paper reviewed research progresses of mechanisms of incidence and regulation, and functions of alternative splicing, as well as the relationship between alternative splicing and diseases.

Key words: alternative splicing, splicing factor, pathogeneses, RNA, isoform