上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

血浆肾上腺髓质素水平对早期异位妊娠的诊断价值

严琦1，陆琦2，王玉东2，赵文霞1   

  1. 1.上海市虹口区江湾医院妇产科， 上海200434； 2.上海交通大学 医学院附属国际和平妇幼保健院妇产科， 上海 200030
  • 出版日期:2015-07-28 发布日期:2015-08-27
  • 通讯作者: 王玉东, 电子信箱: owangyudong@126.com。
  • 作者简介:严琦（1980—）， 女， 本科生; 电子信箱: mickyan1314@163.com。
  • 基金资助:

    上海市虹口区优青培养项目(2013)；上海交通大学“新百人计划”研究项目（XBR2013097）；上海市卫生局基金（20124027）；上海市市级医院适宜技术（SHDC12014208）；上海市科委医学引导项目(15411961100)

Value of plasma adrenomedullin level for diagnosis of early ectopic pregnancy

YAN Qi1, LU Qi2, WANG Yu-dong2, ZHAO Wen-xia1   

  1. 1.Department of Obstetrics and Gynecology, Jiangwan Hospital of Shanghai Hongkou District, Shanghai 200434, China; 2.Department of Obstetrics and Gynecology,  International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2015-07-28 Published:2015-08-27
  • Supported by:

    Outstanding Youth Training Program of Hongkou District of Shanghai, 2013; Program Research Project of New Hundred People Plan, Shanghai Jiao Tong University, XBR2013097; Foundation of Shanghai Municipal Health Bureau, 20124027; Appropriate Technology of Shanghai Municipal Hospitals, SHDC12014208; Medical Guiding Project of the Science and Technology Commission of Shanghai Municipality, 15411961100

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摘要：

目的  探讨血浆中肾上腺髓质素（ADM）在早期异位妊娠中变化情况，研究其对异位妊娠早期诊断的价值。方法  选取2014年3月—12月在上海交通大学医学院附属国际和平妇幼保健院及上海市虹口区江湾医院收治的50例停经5～7周的异位妊娠患者为研究对象，另选取140名正常宫内妊娠者为正常对照组，绘制散点图，观察ADM水平与停经周数的相关性；利用受试者工作特征（ROC）曲线分析ADM的临界点。结果  ①140例正常对照组血浆ADM水平总体趋势是随停经周数的增加而增加，相关系数r为0.283（P<0.05）。②50例异位妊娠组血浆ADM 水平一直处于低值状态，随着停经周数的增加变化不明显，r值为0.186（P>0.05）。③异位妊娠组停经7周的中位数倍数明显低于正常对照组（P<0.05)。④应用ROC曲线分析ADM诊断异位妊娠的临界值（P>0.05）。结论  早期异位妊娠者血浆 ADM水平处于低值状态，随停经周数变化不明显，但作为异位妊娠早期诊断的指标无统计学意义（P>0.05）。

关键词: 肾上腺髓质素, 妊娠早期, 异位妊娠

Abstract:

Objective  To investigate the changes of plasma adrenomedullin (ADM) of patients with early ectopic pregnancy and the value for early diagnose of ectopic pregnancy. Methods  A total of 50 patients with ectopic pregnancy who had menopause for 5-7 weeks were selected as subjects and 140 women with normal singleton pregnancy were selected as controls. All patients were admitted in International Peace Maternity and Child Health Hospital affiliated to Shanghai Jiao Tong University School of Medicine and Jiangwan Hospital of Shanghai Hongkou District from March to December 2014. The scatter diagram was plotted and the correlation between ADM level and weeks of menopause were observed. Critical points of ADM were analyzed by receiver operator characteristic (ROC) curves. Results  ①Being increase with menopause weeks was the overall trend of plasmatic ADM level of 140 controls and the correlation coefficient r was 0.283 (P<0.05). ②The plasmatic ADM levels of 50 patients with ectopic pregnancy were always low, which did not change a lot with the increase of menopause weeks. The correlation coefficient was 0.186 (P>0.05). ③The multiple of median of 7 menopause weeks of patients was obviously lower than that of controls (P<0.05). ④ROC curves was used to analyze critical points of ADM for the diagnosis of ectopic pregnancy (P>0. 05). Conclusion  The ADM levels of patients with early ectopic pregnancy were low and did not change significantly with the increase of menopause weeks, but using it as an index of early diagnosis of ectopic pregnancy is not statistically significant (P>0.05).

Key words: adrenomedullin, early pregnancy, ectopic pregnancy