上海交通大学学报（医学版）

上海交通大学学报（医学版）

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肠内分泌细胞表面甜味与苦味受体的研究进展

李享，朱凯文，高悦，邹广琛，蔡韧，戎伟芳   

  1. 上海交通大学 基础医学院, 上海 200025
  • 出版日期:2015-09-28 发布日期:2015-09-30
  • 通讯作者: 戎伟芳, 电子信箱: weifangrong@hotmail.com。
  • 作者简介:李享（1993—）， 女， 临床医学八年制学生; 电子信箱: 419370630@qq.com。

Research progresses of sweet and bitter taste receptors on surface of enteroendocrine cells

LI Xiang, ZHU Kai-wen, GAO Yue, ZOU Guang-chen, CAI Ren, RONG Wei-fang   

  1. Basic Medicine Faculty of Shanghai Jiao Tong University,Shanghai 200025, China
  • Online:2015-09-28 Published:2015-09-30

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摘要：

动物肠道黏膜上存在表达味觉受体和味觉相关因子的细胞，这些细胞调控着胰高血糖素样肽（GLP）和5-羟色胺（5-HT）等肠道激素的分泌。文章主要介绍了部分存在于消化道黏膜上的肠内分泌细胞和其味觉受体的工作原理、味觉的信号转导途径以及相关肠道激素的分泌机制。以上研究不仅有助于我们了解肠道消化吸收功能的调控机制，也可为糖尿病、肠易激综合征以及化疗药物不良反应的应对提供新的切入点。

关键词: 肠内分泌细胞, 味觉受体, 分泌

Abstract:

Cells representing taste receptors and taste related factors in the mucosa of animal gastrointestinal tract regulate the secretion of intestinal hormones such as glucagon-like peptide (GLP) and 5-hydroxytrypamin (5-HT). This paper introduces enteroendocrine cells that partly locate in the mucosa of gastrointestinal tract and acting mechanisms of their taste receptors, signal transduction of taste, and mechanisms of the secretion of relevant intestinal hormones, which are not only helpful for understanding the regulatory mechanism of digestion and absorption functions of gastrointestinal tract, but also provide new ideas for the remission of diabetes mellitus, irritable bowel syndrome, and adverse reactions of chemotherapy drugs.

Key words: enteroendocrine cells, taste receptors, secretion