上海交通大学学报（医学版）

上海交通大学学报（医学版）

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胰腺恶性肿瘤淋巴结清扫的研究进展

杨宇尘，詹茜，沈柏用   

  1. 上海交通大学 医学院附属瑞金医院普外科胰腺疾病研究所， 上海 200025
  • 出版日期:2015-11-28 发布日期:2016-01-13
  • 通讯作者: 沈柏用, 电子信箱: shenby@shsmu.edu.cn。
  • 作者简介:杨宇尘（1989—）， 男， 博士生; 电子信箱: reggie1989@sjtu.edu.cn。

Research progresses of extended lymphadenectomy for patients with pancreatic adenocarcinoma

YANG Yu-chen, ZHAN Qian, SHEN Bai-yong   

  1. Department of General Surgery, Institute of Pancreatic Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200025， China
  • Online:2015-11-28 Published:2016-01-13

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摘要：

淋巴转移分级是胰腺恶性肿瘤切除预后分析的最重要的影响因素之一，具有重要临床意义。目前，对于胰十二指肠切除术的淋巴结清扫范围仍存在争议。通过对胰十二指肠切除手术中淋巴结清扫范围的循证医学证据的研究发现，扩大淋巴结清扫并没有为胰头癌患者的术后生存带来更多益处。根据胰腺肿瘤复发转移的性质及患者术后生存质量两方面扩大清扫都不具有优势。该文就胰腺恶性肿瘤手术的规范化治疗作一综述。

关键词: 胰腺恶性肿瘤, 标准根治, 扩大淋巴结清扫, 胰十二指肠切除术

Abstract:

Lymph node metastasis and staging of pancreatic adenocarcinoma are the most important factors for analyzing the prognosis of patients who underwent pancreaticoduodenectomy and have important clinical significance. There has been debated on the extent of lymphadenectomy during pancreaticoduodenectomy. Results of evidence based medicine researches show that extended lymphadenectomy has little positive effect on the post-operative survival of patients with pancreatic cancer. No studies support the extended lymphadenectomy according to recurrence and metastasis of pancreatic cancer and the survival quality of patients. This paper reviews the standardized surgical treatment of patients with pancreatic adenocarcinoma.

Key words: pancreatic adenocarcinoma, standard lymphadenectomy, extended lymphadenectomy, pancreaticoduodenectomy