上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

T2 mapping在心肌梗死后心肌水肿检测中的应用以及与血清肌酸激酶间的相关性分析

安东敖蕾1,吴连明1,葛恒2,何奔2,路青1,胡伽尼3，丁海燕4,许建荣1   

  1. 1.上海交通大学 医学院附属仁济医院放射科， 上海 200127； 2.上海交通大学 医学院附属仁济医院心内科， 上海 200127； 3.美国底特律韦恩州立大学放射科， 底特律 48201； 4.清华大学 医学院生物医学影像研究中心， 北京 100084
  • 出版日期:2016-04-28 发布日期:2016-05-26
  • 通讯作者: 许建荣, 电子信箱: xujianrongrj@126.com。
  • 作者简介:安东敖蕾（1989—）， 女， 博士生; 电子信箱: adal118@163.com。
  • 基金资助:

    国家自然基金青年项目（81401403）

Application of T2 mapping in assessment of myocardial edema after infarction and analysis of the correlation between T2 mapping and serum creatine kinase

AN Dong-ao-lei1, WU Lian-ming1, GE Heng2, HE Ben2, LU Qing1, HU Jia-ni3, DING Hai-yan4, XU Jian-rong1   

  1. 1.Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine， Shanghai 200127， China； 2.Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine， Shanghai 200127， China； 3.Department of Radiology, Wayne State University, Detroit 48201, United States； 4.Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University， Beijing 100084， China
  • Online:2016-04-28 Published:2016-05-26
  • Supported by:

    Young Scientists Project of National Natural Science Foundation，81401403

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摘要：

目的 探讨定量T2 mapping在心肌梗死后心肌水肿评估中的应用价值，并对T2值、心肌水肿面积及生化指标肌酸激酶峰值进行相关性分析。方法 回顾性分析心肌梗死再灌注治疗后患者共30例，并于患者冠状动脉介入治疗（PCI）术后2~7 d内对其进行心脏磁共振扫描（CMR）。图像采集完成后，测算并记录心肌梗死后水肿区域及远侧正常心肌的T2值与水肿面积，最后对梗死后水肿区域和远侧心肌T2值进行比较。并将患者血清肌酸激酶与T2 mapping中所测算的T2值及水肿面积分别进行相关性分析。结果 ①心肌梗死后水肿区域T2信号显著高于远侧正常心肌，T2值分别为（59.18±4.23）ms及（43.35±2.11）ms（P=0.013)。②通过T2 mapping测算所得的心肌水肿区域面积与血清肌酸激酶峰值指标呈正相关（r=0.82，P=0.000）。③水肿区域T2值与血清肌酸激酶峰值间相关性欠佳（r=0.475，P=0.054）。结论 定量T2 mapping在急性心肌梗死后心肌水肿的评估中非常有价值，而急性心肌梗死后的心肌水肿面积对心肌损伤评估可能更为重要。

关键词: T2 mapping, 急性心肌梗死, 肌酸激酶, 心脏磁共振

Abstract:

Objective To explore the application of quantitative T2 mapping for assessing the myocardial edema after myocardial infarction (MI) and analyze the correlation between T2 value, area of myocardial edema, and the peak value of biochemical index creatine kinase (CK). Methods Thirty patients with MI who underwent reperfusion therapy were retrospectively analyzed. Patients received cardiac magnetic resonance imaging (CMR) within 2-7 d after percutaneous coronary intervention (PCI). T2 values of edema region and distal normal myocardium and the area of edema were calculated and documented after images were collected. T2 values of edema region and distal normal myocardium were compared. The correlation of T2 values and the area of edema calculated via T2 mapping with serum CK was analyzed. Results ①T2 value [(59.18 ± 4.23)ms] of edema region was significantly higher than that of distal normal myocardium [(43.35 ± 2.11) ms](P=0.013). ②The area of edema region calculated via T2 mapping was positively correlated to the peak value of serum CK (r=0.82, P=0.000). ③T2 value of edema region was not correlated to the peak value of serum CK (r=0.475, P=0.054). Conclusion Quantitative T2 mapping is valuable for the assessment of myocardial edema in acute MI. The area of myocardial edema may be more important for the assessment of myocardial injury after acute MI.

Key words: T2 mapping； acute myocardial infarction； creatine kinase, cardiac MRI