上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

IRS-1基因与抑郁症及伴随焦虑症状的关联研究

王凡，张晨，李则挚，李豪喆，方贻儒   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科， 上海 200030
  • 出版日期:2016-04-28 发布日期:2016-05-26
  • 通讯作者: 方贻儒, 电子信箱: yirufang@gmail.com。
  • 作者简介:王凡（1990—）， 女， 硕士生; 电子信箱: beauty--2008@hotmail.com。
  • 基金资助:

    国家自然科学基金（91232719）；国家临床重点专科-上海市精神卫生中心（卫生部医政司2011-873）；科技部“十二五”国家科技支撑项目 (2012BAI01B04)

Correlation of IRS-1 gene between depression and accompanying anxiety symptoms

WANG Fan, ZHANG Chen, LI Ze-zhi, LI Hao-zhe, FANG Yi-ru   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine， Shanghai 200030， China
  • Online:2016-04-28 Published:2016-05-26
  • Supported by:

    National Natural Science Foundation of China， 91232719； National Key Clinical Disciplines—Shanghai Mental Health Center，2011-873； National Key Technology Research and Development Program of the Ministry of Science and Technology of China in the “12th Five-Year Plan”， 2012BAI01B04

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摘要：

目的 探讨胰岛素受体底物1（IRS-1）基因rs10178202和rs2272205单核苷酸多态性与抑郁症及伴随焦虑症状的关系。方法 提取中国汉族585例抑郁症患者（病例组）和658名健康对照者（对照组）基因组DNA，采用TaqMan探针SNP基因分型技术测定IRS-1基因rs10178202和rs2272205位点的基因分型，检测病例组及对照组基因型的频率分布差异。结果 病例组与对照组中两个SNP基因型分布均符合Hardy-Weinberg平衡定律；病例组与对照组rs10178202和rs2272205基因型和等位基因频率分布的差异均无统计学意义；病例组中Hamilton抑郁量表第7项因子分肌肉系统症状与rs10708202位点T等位基因相关（OR=0.45，95%CI 0.22~0.89，P=0.02)；第8项、第13项因子分阳性与否均与年龄相关（OR=1.03，95%CI 1.00~1.06，P=0.04；OR=1.03， 95%CI 1.00~1.06，P=0.04），年龄是发生焦虑的危险因素。结论 IRS-1基因rs10178202和rs2272205与抑郁症无明显关联，可能与伴随焦虑症状有关；年龄是伴有感觉系统症状和自主神经系统症状的危险因素。

关键词: 抑郁症, IRS-1, 焦虑症状, 单核苷酸多态性, HAMA-14

Abstract:

Objective To explore the correlation of the single nucleotide polymorphism in loci rs10178202 and rs2272205 of insulin receptor substrate 1 (IRS-1) gene with depression and accompanying anxiety symptoms. Methods Genome DNA of 585 Han patients with depression (case group) and 658 healthy controls (control group) were extracted. Genotypes in loci rs10178202 and rs2272205 of IRS-1 gene were detected by Taqman SNP genotyping technology. The difference in frequency distribution of genotypes between the case group and the control group was detected. Results The genotype distributions of two SNPs in two groups were consistent with the Hardy-Weinberg equilibrium. The differences in genotype and allele frequency in loci rs10178202 and rs2272205 between two groups were not statistically significant. The 7th factor of the HAMA scale was correlated with allele T in loci rs10708202 (OR=0.45, 95%CI 0.22-0.89, P=0.02). Both the 8th and 13th factors were correlated with age (OR=1.03, 95%CI 1.00-1.06, P=0.04; OR=1.03, 95%CI 1.00-1.06, P=0.04) and age was a risk factor of anxiety symptoms. Conclusion Loci rs10178202 and rs2272205 of IRS-1 gene are not significantly associated with depression, but may be associated with accompanying anxiety symptoms. Age is a risk factor of accompanying sensory system and autonomic nervous system symptoms.

Key words: depression, IRS-1, anxiety symptom, single nucleotide polymorphism, HAMA-14