上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

精神康复干预和ERP诊疗新技术联合应用在精神分裂症康复中的作用

吴雪芬1，陈良虎1，王爱华1，陈冲2   

  1. 1.上海市浦东新区南汇精神卫生中心精神科， 上海 201399； 2.上海交通大学 医学院附属精神卫生中心神经生理室， 上海 200030
  • 出版日期:2016-04-28 发布日期:2016-05-26
  • 作者简介:吴雪芬（1977—）， 女， 主治医师， 本科; 电子信箱: 1045296269@qq.com。

Effects of combination of psychic rehabilitation intervention and ERP applied to the rehabilitation of schizophrenia

WU Xue-fen1, CHEN Liang-hu1, WANG Ai-hua1, CHEN Chong2   

  1. 1.Department of Psychiatric, Nanhui Mental Health Center, Pudong New District, Shanghai 201399, China； 2.Department of Electrophysiology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2016-04-28 Published:2016-05-26

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摘要：

目的 探讨精神康复干预（PRI）和事件相关脑电位（ERP）诊疗新技术联合应用在精神分裂症康复中的作用及干预效果。方法 将96例精神分裂症患者随机分成研究组和对照组，每组48例。采用PRI和ERP对精神分裂症进行康复治疗。结果 ①实施PRI后，研究组患者的简明精神病评定量表（BPRS）、社会功能缺陷测定（SDSS）减分值以及治疗依从性问卷增分值均显著高于对照组(P<0.05或0.01)。②实施PRI后，研究组患者家属的精神症状自评量表（SCL-90）各因子减分值显著高于对照组(P<0.05或0.01)。③研究组随着症状缓解，ERP检测中的主要指标靶刺激P2、P3波幅也随之改善（P<0.05或0.01）。结论 PRI治疗对患者恢复社会功能、患者家属心理健康状况均有显著的效果。

关键词: 精神康复干预, 事件相关脑电位, 精神分裂症

Abstract:

Objective To explore the effects of novel diagnosis and treatment technologies combination of psychic rehabilitation intervention (PRI) and event related potentials (ERP)  applied to the rehabilitation of schizophrenia and intervention outcomes. Methods Ninety-six patients with schizophrenia were randomly assigned to the study group and the control group with 48 patients per group. PRI and ERP were used to perform rehabilitation treatment for patients. Results ①After the implementation of PRI, the decrease in the scores of Brief Psychiatric Rating Scale (BPRS) and Social Disability Screening Schedule (SDSS) and the increase in the scores of Medication Adherence Rating Scale (MARS) in the study group were greater as compared with the control group (P<0.05 or 0.01). ②After the implementation of PRI, the decrease in the scores of all factors in Symptom Checklist 90 (SCL-90) in the study group were much greater as compared with the control group (P<0.05 or 0.01). ③For the study group, P2, P3 amplitudes of the target stimulus, which were major indexes in ERP test, improved with the remission of symptoms (P<0.05 or 0.01). Conclusion PRI treatment has significant efficacy for improving patients social functions and family members mental health.

Key words: psychic rehabilitation intervention, event related potential, schizophrenia