上海交通大学学报（医学版）

上海交通大学学报（医学版）

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离子通道在哮喘发病机制中作用的研究进展

蔡上逍1，菅朝慧1，顾豪1，何白慧1，江一鸣1,2   

  1. 上海交通大学 1.基础医学院2012级临床医学八年制， 上海 200025； 2.医学院附属仁济医院耳鼻咽喉科， 上海 200127
  • 出版日期:2016-04-28 发布日期:2016-05-26
  • 通讯作者: 江一鸣, 电子信箱: yvon998@126.com。
  • 作者简介:蔡上逍（1992—）， 女， 2012级临床医学八年制本科生; 电子信箱: sunshine920920@163.com。
  • 基金资助:

    国家自然科学基金（91413122）

Research progress of ion channels in the mechanism of asthma

CAI Shang-xiao1, JIAN Chao-hui1, GU Hao1, HE Bai-hui1, JIANG Yi-ming1,2   

  1. 1.Eight-year MD Program, Institute of Medical Sciences, Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China; 2.Department of Otorhinolaryncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2016-04-28 Published:2016-05-26
  • Supported by:

    National Natural Science Foundation of China, 91413122

PDF (PC)

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摘要：

近年来，支气管哮喘（简称哮喘）的全球发病率呈上升趋势，因此，哮喘发病机制及治疗靶点的相关研究也越来越深入和广泛。目前发现与哮喘相关的离子通道包括钙离子通道、钾离子通道、上皮钠离子通道、酸敏感离子通道及瞬时感受器电位通道等。该文对离子通道在哮喘发病机制中作用的研究进展以及不同离子通道作为哮喘治疗靶点的应用前景进行综述。

关键词: 离子通道, 支气管哮喘, 支气管平滑肌痉挛, 变态反应性气道炎症

Abstract:

In recent years, the prevalence of bronchial asthma (asthma for short) is increasing globally. Thus, more thorough and broad studies on pathogenesis and therapeutic targets of asthma have been carried out. Identified ion channels that are associated with asthma include Ca2+ channels, K+ channels, epithelial sodium channels, acid-sensing ion channels, and transient receptor potential channels, etc. In this review we present research progresses of pathogenesis of asthma and the prospect of applying different ion channels as therapeutic targets of asthma.

Key words: ion channels; , bronchial asthma; , bronchial smooth muscle spasm, allergic airway inflammation