上海交通大学学报（医学版）

上海交通大学学报（医学版）

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LncRNAs在血管性疾病中的作用

黄椿媚，王晓，葛勤敏   

  1. 上海交通大学  医学院附属新华医院急诊科， 上海 200092
  • 出版日期:2016-04-28 发布日期:2016-05-26
  • 通讯作者: 葛勤敏, 电子信箱: geqinmin@126.com。
  • 作者简介:黄椿媚（1988—）， 女， 硕士生; 电子信箱: huangchunmeijy@126.com。
  • 基金资助:

    国家自然科学基金（81000354）；上海市自然科学基金（14ZR1427000）

Role of LncRNAs in vascular diseases

HUANG Chun-mei, WANG Xiao, GE Qin-min   

  1. Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2016-04-28 Published:2016-05-26
  • Supported by:

    National Natural Science Foundation of China， 81000354; Natural Science Foundation of Shanghai， 14ZR1427000

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摘要：

血管性疾病一直是威胁人类健康的重大问题，其关键病理特征为血管平滑肌细胞异常增殖和新生内膜的形成病变。近来有证据表明非编码RNA在组织稳态和病理生理调节中起重要作用。除微小RNA（miRNA）外，长链非编码RNA（LncRNAs）可在不同阶段基因表达和信号通路中发挥作用。LncRNAs最近被发现在血管发育、谱系提交和中胚层向心脏分化中起作用；且与血管紧张素Ⅱ活动及血管性疾病，包括心脏疾病和动脉粥样硬化相关。LncRNAs可能在血管发育及相关疾病中介导许多不同的途径。该文主要对LncRNAs在血管性疾病中的作用进行综述。

关键词: 长链非编码RNA, 血管性疾病, 血管发育

Abstract:

Vascular diseases are a serious problem that threats human health with key pathological characteristics of aberrant proliferation of vascular smooth muscle cells and formation of neointimal lesions. Recent evidence has demonstrated that non-coding RNAs play an important role in the regulation of tissue homeostasis and pathophysiological conditions. Besides microRNAs (miRNAs), long non-coding RNAs (LncRNAs) contribute to gene expression and signaling pathway at various stages. Recently, LncRNAs have been identified to play a role in vascular development, lineage commitment, and mesoderm differentiation into heart and to be associated with angiotensin Ⅱ actions and vascular diseases, including heart diseases and atherosclerosis. LncRNAs may mediate many different pathways in vascular development and related diseases. This review mainly discusses the role of LncRNAs in vascular diseases.

Key words: long noncoding RNAs, vascular disease, vascular development