上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

儿童失神癫痫的事件相关脑电位N400实验研究

徐璐1，吴荣琴1，吕坚1，黄军斌1，唐佳琳1，陈兴时2，陈冲2   

  1. 1.上海市闸北区精神卫生中心， 上海 200436； 2.上海交通大学 医学院附属精神卫生中心， 上海 200030
  • 出版日期:2016-05-28 发布日期:2016-05-26
  • 通讯作者: 吴荣琴, 电子信箱: rongrong0707@126.com。
  • 作者简介:徐璐（1979—）， 女， 主治医师， 学士; 电子信箱: sunnyxl98@126.com。
  • 基金资助:

    上海市自然科学基金（13ZR1439300）

Experimental study on event-related potential N400 in childhood absence epilepsy

XU Lu1, WU Rong-qin1, LÜ Jian1, HUANG Jun-bin1, TANG Jia-lin1, CHEN Xing-shi2, CHEN Chong2   

  1. 1.Department of Psychiatry, Shanghai Zhabei Mental Health Center, Shanghai 200436, China； 2.Department of Neurophysiology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2016-05-28 Published:2016-05-26
  • Supported by:

    Shanghai Natural Science Foundation， 13ZR1439300

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摘要：

目的 探讨儿童失神癫痫（CAE）的事件相关脑电位N400的变异。方法 应用中国润杰WJ-1型ERP仪，采用汉语正常句子结尾词（匹配）与句子结尾歧义词（非匹配）的模式，对45例CAE和42名正常儿童进行N400检测。结果 ①潜伏期：CAE组的N400潜伏期在3个脑区明显延迟于对照组。CAE组在Cz脑区，匹配指标（P<0.01）、非匹配指标（P<0.01）均延迟于对照组；CAE组在Fz、Pz脑区也有类似变化。②波幅： CAE组的N400波幅在5个脑区明显低于对照组。CAE组在Cz脑区，匹配指标（P<0.01）、非匹配指标（P<0.01）均低于对照组。结论 句子结尾词是引起N400的良好刺激材料，可用于神经精神科临床，特别适合CAE的辅助诊断。

关键词: 儿童失神癫痫, 正常儿童, 事件相关脑电位, N400, 诊断

Abstract:

Objective To investigate variations of event related potential N400 in childhood absence epilepsy (CAE). Methods The Guangzhou Runjie WJ-1 ERP instrument was employed to perform N400 tests for 45 cases of CAE and 42 normal children by the use of model of normal words (matching) and ambiguous words (mismatching) ended Chinese sentences. Results  ①Latency. Compared with the control group, the CAE group showed prolonged N400 latency in three encephalic regions (Cz、Fz, and Pz), especially for both matching (P<0.01) and mismatching (P<0.01) indexes in the Cz region, as well as in Fz and Pz regions. ②Amplitude. Compared with the control group, the CAE group also showed much lower N400 amplitude in five encephalic regions, especially for both matching (P<0.01) and mismatching (P<0.01) indexes in the Cz region. Conclusion Sentence ending words are a favorable stimulus to elicit N400, which can be used for clinical neurology, especially for auxiliary diagnosis of CAE.

Key words: childhood absence epilepsy, normal children, event-related potential, N400, diagnosis