上海交通大学学报（医学版）

上海交通大学学报（医学版）

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非编码RNA在多囊卵巢综合征中的作用研究进展

杨倩1，周承亮2，潘洁雪1，黄荷凤1，2   

  1. 1.上海交通大学  医学院附属国际和平妇幼保健院胚胎源性疾病研究所， 上海 200030; 2.浙江大学  医学院附属妇产科医院生殖遗传教育部重点实验室， 杭州310058
  • 出版日期:2016-06-28 发布日期:2016-07-25
  • 作者简介:杨倩（1992—）， 女， 硕士生; 电子信箱: liyiqian@sjtu.edu.cn。
  • 基金资助:

    国家科技支撑计划（2012BAI32B00）；国家自然科学基金（81450038）

Research advances in the roles of ncRNAs in polycystic ovary syndrome

YANG Qian1, ZHOU Cheng-liang2, PAN Jie-xue1, HUANG He-feng1，2   

  1. 1.Institute of Embryo-Fetal Original Adult Disease, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030， China; 2.The Key Laboratory of Reproductive Genetics（Ministry of Education）， Womens Hospital School of Medicine Zhejiang University, Hangzhou 310058， China
  • Online:2016-06-28 Published:2016-07-25
  • Supported by:

    The National Key Technology R&D Program， 2012BAI32B00； National Natural Science Foundation of China， 81450038

PDF (PC)

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摘要：

多囊卵巢综合征（PCOS）是一种常见的生殖系统疾病，影响着5%～10%育龄妇女的健康。尽管对其发病机制的研究不断深入，但其发病机制仍不明确。非编码RNA（ncRNA）指不翻译为蛋白的RNA，主要参与基因表达调控、表观遗传学调控等重要功能，近年来逐渐成为研究热点。研究发现多种ncRNA在PCOS患者的血清、卵泡液和颗粒细胞中表达量发生改变，并可能作为PCOS诊断的新靶点，这为PCOS发病机制的研究提供新思路。该文综述了近年来ncRNA在PCOS疾病发生发展中作用的研究进展。

关键词: 多囊卵巢综合征, 非编码RNA, 微RNA, 长链非编码RNA

Abstract:

Polycystic ovary syndrome (PCOS) is a common reproductive system disease affecting approximately 5% to 10% of women of childbearing age. The pathogenesis of PCOS remains unclear despite increasing studies in recent years. ncRNAs are RNAs not translating into proteins and mainly involve in many important functions such as regulation of gene expression and epigenetics. ncRNAs become a research hotspot recently. Previous studies have found changes in expressions of various ncRNAs in serum, follicle fluid, and granulosa cells of PCOS patients. It may be a new target for the diagnose of PCOS and provide new idea for studying the pathogenesis of PCOS. This paper reviews recent research advances in the roles of ncRNA in the occurrence and development of PCOS.

Key words: polycystic ovary syndrome, ncRNA, microRNA, lncRNA