上海交通大学学报（医学版）
• 综述 • 上一篇 下一篇
赵巧云，谢勇
出版日期:
发布日期:
通讯作者:
作者简介:
基金资助:
国家自然科学基金（81260076）
ZHAO Qiao-yun, XIE Yong
Online:
Published:
Supported by:
National Natural Science Foundation of China, 81260076
摘要：
幽门螺杆菌是胃内一种长期慢性感染致病菌，其外膜蛋白（OMPs）包括脂蛋白、菌毛蛋白及一些黏附因子。这些黏附因子与幽门螺杆菌的黏附定植、持续感染和疾病的严重程度密切相关，而黏附是幽门螺杆菌定植及致病的关键。研究减弱黏附作用的疫苗已经成为当前的热点。该文就与黏附有关的OMPs、黏附受体、黏附机制及相关疫苗的研究进展作一综述。
关键词: 幽门螺杆菌, 外膜蛋白, 黏附, 疫苗
Abstract:
Helicobacter pylori is a predominant pathogen inducing long-term chronic infection of stomach. Its outer membrane proteins (OMPs) mainly include lipoprotein, fimbriae protein and some adhesions. The adhesions are closely related to the pathogenic processes of adherence, colonization, persistent infection and severe clinical outcomes. In addition, the fact that adherence is vital for colonization and pathogenicity has made it a focus to study the vaccines against adherence. The OMPs related to adherence, their receptors, mechanisms of adherence, and the vaccines are summarized in this review.
Key words: Helicobacter pylori, outer membrane proteins, adherence, vaccine
赵巧云，谢勇. 幽门螺杆菌外膜蛋白与黏附机制的研究进展[J]. 上海交通大学学报（医学版）, doi: 10.3969/j.issn.1674-8115.2017.02.024.
ZHAO Qiao-yun, XIE Yong . Research progress of mechanisms outer membrane proteins of Helicobacter pylori and its adherence[J]. , doi: 10.3969/j.issn.1674-8115.2017.02.024.
0 / / 推荐
导出引用管理器 EndNote|Ris|BibTeX
链接本文: https://xuebao.shsmu.edu.cn/CN/10.3969/j.issn.1674-8115.2017.02.024
https://xuebao.shsmu.edu.cn/CN/Y2017/V37/I02/249
