上海交通大学学报（医学版）

上海交通大学学报（医学版）

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幽门螺杆菌外膜蛋白与黏附机制的研究进展

赵巧云，谢勇   

  1. 南昌大学第一附属医院消化内科，南昌 330006
  • 出版日期:2017-02-28 发布日期:2017-02-28
  • 作者简介:赵巧云（1990—），女，硕士生；电子信箱：15083821971@163.com。
  • 基金资助:

    国家自然科学基金（81260076）

Research progress of mechanisms outer membrane proteins of Helicobacter pylori and its adherence

ZHAO Qiao-yun, XIE Yong   

  1. Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
  • Online:2017-02-28 Published:2017-02-28
  • Supported by:

    National Natural Science Foundation of China, 81260076

PDF (PC)

1792

摘要：

幽门螺杆菌是胃内一种长期慢性感染致病菌，其外膜蛋白（OMPs）包括脂蛋白、菌毛蛋白及一些黏附因子。这些黏附因子与幽门螺杆菌的黏附定植、持续感染和疾病的严重程度密切相关，而黏附是幽门螺杆菌定植及致病的关键。研究减弱黏附作用的疫苗已经成为当前的热点。该文就与黏附有关的OMPs、黏附受体、黏附机制及相关疫苗的研究进展作一综述。

关键词: 幽门螺杆菌, 外膜蛋白, 黏附, 疫苗

Abstract:

Helicobacter pylori is a predominant pathogen inducing long-term chronic infection of stomach. Its outer membrane proteins (OMPs) mainly include lipoprotein, fimbriae protein and some adhesions. The adhesions are closely related to the pathogenic processes of adherence, colonization, persistent infection and severe clinical outcomes. In addition, the fact that adherence is vital for colonization and pathogenicity has made it a focus to study the vaccines against adherence. The OMPs related to adherence, their receptors, mechanisms of adherence, and the vaccines are summarized in this review.

Key words: Helicobacter pylori, outer membrane proteins, adherence, vaccine