上海交通大学学报（医学版）

上海交通大学学报（医学版）

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力学失稳态导致骨关节炎的机制研究进展

纪安琪，邓国英，王秋根，王谦   

  1. 上海交通大学附属第一人民医院创伤中心创伤骨科，上海 201600
  • 出版日期:2017-04-28 发布日期:2017-05-04
  • 通讯作者: 王谦，电子信箱：drwangqian23@126.com。
  • 作者简介:纪安琪（1993—），男，本科生；电子信箱：jianqi@sjtu.edu.cn。
  • 基金资助:

    上海市科委引导项目（15411968800）；上海市自然科学基金（13ZR1433300）；上海市第一人民医院优秀医学青年人才培养前期计划（061417）；上海
    市第一人民医院创伤急救中心学科建设经费（院重1304）

Research advances in the mechanism of osteoarthritis caused by the mechanical instability

JI An-qi, DENG Guo-ying, WANG Qiu-gen, WANG Qian   

  1. Department of Orthopedics, Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 201600, China
  • Online:2017-04-28 Published:2017-05-04
  • Supported by:

    Shanghai Municipal Science and Technology Commission Guidance Project, 15411968800; Shanghai Natural Science Foundation, 13ZR1433300; The Preliminary Plan of Excellent Medical Young Talents Training in Shanghai General Hospital, 061417; Discipline Construction Funds of Trauma Emergency Center of Shanghai General Hospital, 1304

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摘要：

骨关节炎是一种常见的关节软骨退行性疾病，力学失稳态是骨关节炎发病的较为经典的原因。力学失稳态可以通过直接损伤、诱导细胞凋亡和刺激炎症因子生成，来减少软骨细胞数量和破坏软骨细胞外基质，导致基质中的Ⅱ型胶原蛋白和蛋白多糖减少，使软骨发生退变，长期作用可导致骨关节炎的发生。因此，了解力学失稳态如何导致骨关节炎发生能更好地从力学角度改善骨关节炎的病程。

关键词: 骨关节炎, 力学失稳态, 细胞外基质

Abstract:

Osteoarthritis is a common articular cartilage degenerative disease and the main cause is mechanical instability. The mechanical instability can reduce the number of chondrocytes and destroy extracellular matrix through direct injury, inducing cell apoptosis, and stimulating the production of inflammatory factors, leading to decrease of matrix type II collagen and proteoglycan and degeneration of cartilage. Long-term cartilage degeneration can result in osteoarthritis. Therefore, understanding how mechanical instability leads to the incidence of osteoarthritis can better improve the course of osteoarthritis from the perspective of mechanics.

Key words: osteoarthritis, mechanical instability, extracellular matrix