上海交通大学学报(医学版) ›› 2022, Vol. 42 ›› Issue (11): 1627-1632.doi: 10.3969/j.issn.1674-8115.2022.11.016
• 综述 • 上一篇
收稿日期:
2022-07-15
接受日期:
2022-10-18
出版日期:
2022-11-28
发布日期:
2023-01-04
通讯作者:
张文杰
E-mail:18314142029@163.com;wenjieboshi@aliyun.com
作者简介:
董玉山(1998—),男,硕士生;电子信箱:18314142029@163.com。
基金资助:
Received:
2022-07-15
Accepted:
2022-10-18
Online:
2022-11-28
Published:
2023-01-04
Contact:
ZHANG Wenjie
E-mail:18314142029@163.com;wenjieboshi@aliyun.com
Supported by:
摘要:
骨关节炎(osteoarthritis,OA)是一种临床常见的关节病变,多累及下肢负重关节,易导致关节畸形,严重影响生活质量。目前,OA的早期治疗主要集中在对症治疗及减缓关节软骨的磨损。各类细胞因子在OA的发生和发展过程中发挥重要作用。白细胞介素(interleukin,IL)家族中,IL-1β/6/8与OA的发生及进展有关,是主要的致炎因子;IL-4/10作为抗炎成分,对关节起保护作用。肿瘤坏死因子-α也是促进关节炎症发生的主要成分。体内外研究表明,转化生长因子-β、胰岛素样生长因子、成纤维细胞生长因子在延缓OA的进展过程中发挥积极作用。研究相关细胞因子的作用,不仅可以深入了解OA的发病机制,也可为OA的治疗提供新思路,有望解决当下OA传统治疗效果不理想的问题。目前,在细胞因子应用于OA的防治领域,已经获得了很多有益的研究成果,部分已经进入临床试验和应用。该文综述了几类对于OA防治具有潜在效果的细胞因子的研究进展和部分作用机制。
中图分类号:
董玉山, 张文杰. 细胞因子治疗骨关节炎的研究进展[J]. 上海交通大学学报(医学版), 2022, 42(11): 1627-1632.
DONG Yushan, ZHANG Wenjie. Research progress of cytokines in treatment of osteoarthritis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(11): 1627-1632.
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