上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (9): 1266-.doi: 10.3969/j.issn.1674-8115.2017.09.013

• 综述 • 上一篇    下一篇

白介素 17 与精神分裂症的相关性研究进展

方新宇，张晨   

  1. 上海交通大学 医学院附属精神卫生中心生化研究室，上海 200030
  • 出版日期:2017-09-28 发布日期:2017-10-10
  • 通讯作者: ?张晨，电子信箱：zhangchen645@gmail.com
  • 作者简介:方新宇（1991—），男，硕士生；电子信箱：fxywilbur@163.com
  • 基金资助:
    国家自然科学基金（81000581，81471358）；国家临床重点专科- 上海市精神卫生中心（卫计委医政司2011-873）；上海市科学技术发展基金 （12140904200）；上海市教育委员会高峰高原学科建设计划（20152530）

Research progress of correlation between interleukin-17 and schizophrenia#br#

FANG Xin-yu, ZHANG Chen   

  1. Biochemical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China
  • Online:2017-09-28 Published:2017-10-10
  • Supported by:
    National Natural Science Foundation of China, 81000581, 81471358; National Key Clinical Discipline at Shanghai Mental Health Center, OMA-MH 2011-873; Shanghai Science and Technology Development Funds, 12140904200; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152530

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摘要：  精神分裂症是一种重性精神疾病，反复发作，预后差，给家庭和社会带来沉重负担，但其病因和发病机制尚未被完全阐明。 研究发现精神分裂症患者免疫系统存在异常。白介素等细胞因子作为免疫系统的重要组成部分，与精神分裂症的病因和发病机制存在 重要关联。该文对白介素 17 与精神分裂症的相关性研究进行了综述。

关键词: 精神分裂症, 细胞因子, 白介素 17

Abstract:

Schizophrenia is a severe, recurrent mental disorder with a poor prognosis and brings a great burden to patients' family and society. However, its etiology and pathogenesis have not been fully elucidated. Previous studies have implicated abnormalities of the immune system in schizophrenia. Besides, it has also been shown that there does exist a significant association between schizophrenia and interleukins, a kind of cytokine as an important component of the immune system. The present review aims to provide an updated overview of the relevance between interleukin-17 and schizophrenia.

Key words: schizophrenia, cytokine, interleukin-17