上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (11): 1570-.doi: 10.3969/j.issn.1674-8115.2017.11.021

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代谢组学在糖尿病慢性并发症及血糖波动研究中的应用

陈树青，陆静毅，马晓静，周健   

  1. 上海交通大学附属第六人民医院内分泌代谢科，上海市糖尿病研究所，上海市糖尿病重点实验室，上海市糖尿病临床医学中心，上海 200233
  • 出版日期:2017-11-28 发布日期:2018-01-10
  • 作者简介:陈树青（1994—），女，硕士生；电子信箱：shuqing_chen@sina.cn
  • 基金资助:
     上海市教育委员会高峰高原学科建设计划（20161430）；上海市自然科学基金（17ZR1421300）

Recent progress in metabolomics with regard to diabetic complications and glucose fluctuation#br#

CHEN Shu-qing, LU Jing-yi, MA Xiao-jing, ZHOU Jian   

  1. Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai 200233, China
  • Online:2017-11-28 Published:2018-01-10
  • Supported by:
    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20161430; Natural Science Foundation of Shanghai, 17ZR1421300

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摘要： 糖尿病是严重威胁人类健康的一种常见代谢性疾病，其多种并发症是糖尿病致残、致死的主要原因。近年来的研究表明，血 糖波动对糖尿病慢性并发症的发生发展具有重要作用。代谢组学作为识别生物体整体代谢变化的一门新学科，为糖尿病及其并发症研 究提供了一种新思路。该文对代谢组学领域中糖尿病慢性并发症及血糖波动方面的研究进展进行综述。

关键词: 代谢组学, 血糖波动, 糖尿病并发症, 糖尿病

Abstract:

Diabetes mellitus is a common metabolic disease and poses serious threat to human health. Diabetic complications are the major causes of both morality and disability. In recent years, studies show that the glucose fluctuation plays an important role in the development of chronic diabetic complications. As a new discipline to identify the overall metabolic changes of living organisms, metabolomics provides new insights into the study of diabetes and diabetic complications. In this paper, the recent studies on the development of chronic diabetic complications and blood glucose fluctuation in the field of metabolomics were reviewed.

Key words: metabolomics, glucose fluctuation, diabetic complications, diabetes mellitus

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