上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (3): 322-.doi: 10.3969/j.issn.1674-8115.2019.03.018

• 综述 • 上一篇    下一篇

肠道微生物与物质依赖关系的研究进展

邓頔，赵敏   

  1. 上海交通大学医学院附属精神卫生中心物质依赖与成瘾科，上海 200030
  • 出版日期:2019-03-28 发布日期:2019-04-28
  • 作者简介:邓頔（1994—），女，回族，博士生；电子信箱： di_deng1994@163.com。
  • 基金资助:
    国家自然科学基金（ 81771436）；上海市优秀学术带头人计划（ 17XD1403300）；上海市重中之重重点学科（ 2017ZZ02021）

Research progress of gut microbiota in substance dependence

DENG Di, ZHAO Min   

  1. Department of Substance Dependence and Addiction, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2019-03-28 Published:2019-04-28
  • Supported by:
    National Natural Science Foundation of China, 81771436; Program of Shanghai Academic Research Leader, 17XD1403300; Shanghai “Top Priority”Key Discipline, 2017ZZ02021)。

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摘要： 物质依赖在全球范围内造成巨大的疾病负担和经济负担，其发生机制尚不明确，且缺乏有效的干预措施。近年来，越来越多的研究表明，肠道微生物与物质依赖存在密切关系，肠道微生物不仅受到成瘾物质的影响，而且在物质依赖的发生发展中起到调控作用。该文综述了肠道微生物在目前使用最为广泛的几种成瘾物质中的研究进展，以期为物质依赖的机制研究以及诊断和防治措施的开发提供新的思路。

关键词: 肠道微生物, 物质依赖, 酒精, 尼古丁, 阿片类物质, 中枢神经兴奋剂, 大麻

Abstract:

Substance dependence is a pervasive worldwide problem, of which the mechanism remains unclear, and there is no effective intervention. In recent years, it has been showed that the gut microbiota is closely related to substance dependence. As discussed in this review, gut microbiota is significantly affectedthe substances of abuse, and may serve as an important regulator in the development of substance dependence. This article reviews the research progress of gut microbiota in the most widely used substances, into provide ideas for future studies on underlying mechanisms and further interventions in substance dependence.

Key words: gut microbiota, substance dependence, alcohol, nicotine, opioids, central nerve system stimulants, cannabis

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