上海交通大学学报(医学版) ›› 2022, Vol. 42 ›› Issue (5): 667-672.doi: 10.3969/j.issn.1674-8115.2022.05.016
康文慧1(), 陈仪婷1, 赵安达2, 李荣1, 李生慧1(
)
收稿日期:
2022-02-22
接受日期:
2022-05-22
出版日期:
2022-05-28
发布日期:
2022-05-28
通讯作者:
李生慧
E-mail:18717805230@163.com;lsh9907@163.com
作者简介:
康文慧(1997—),女,硕士生;电子信箱:18717805230@163.com。
基金资助:
KANG Wenhui1(), CHEN Yiting1, ZHAO Anda2, LI Rong1, LI Shenghui1(
)
Received:
2022-02-22
Accepted:
2022-05-22
Online:
2022-05-28
Published:
2022-05-28
Contact:
LI Shenghui
E-mail:18717805230@163.com;lsh9907@163.com
Supported by:
摘要:
褪黑素(melatonin)是由松果体分泌的激素之一,其调控昼夜节律和改善睡眠的功效已被广泛研究和证实。已有研究认为褪黑素过量或分泌紊乱能导致不良的健康效应。近年来,不断积累的证据显示褪黑素在抗炎、抗癌、免疫调节等方面发挥重要作用。加之褪黑素不仅可以在人体合成,且易于通过外源性途径获取,因此,其对人体健康的影响备受关注。该文以褪黑素参与气道炎症和气道重塑调控为切入点,系统检索、筛选了截至2022年2月的相关文献37篇,分析了褪黑素对哮喘的影响及相关机制。结果显示,褪黑素一方面可以通过抑制磷酸化信号通路影响基因转录、翻译,阻断核因子κB(nuclear factor-κB,NF-κB)的激活,进而改变呼吸道细胞因子和炎症细胞的表达,减少嗜酸性粒细胞等炎症细胞的生成和募集,抑制白细胞介素-1β(interleukin-1β,IL-1β)、IL-4、IL-6、胱天蛋白酶-1(caspase-1)等细胞因子和酶,减少黏液的产生,发挥抑制气道炎症的作用,并可以拮抗哮喘的外源性加重和特应性进程。另一方面,褪黑素能够通过作用于基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9),减少胶原沉积,抑制杯状细胞增生,改善平滑肌细胞表型而实现抑制气道重塑。上述结论均提示褪黑素具有通过气道炎症和气道重塑调控哮喘发病进程的潜力,围绕褪黑素的免疫调节功能开展深入探索有望为哮喘防治提供新思路。
中图分类号:
康文慧, 陈仪婷, 赵安达, 李荣, 李生慧. 褪黑素在哮喘发病和病程中的作用机制研究进展[J]. 上海交通大学学报(医学版), 2022, 42(5): 667-672.
KANG Wenhui, CHEN Yiting, ZHAO Anda, LI Rong, LI Shenghui. Research progress of the mechanism of melatonin in the pathogenesis and course of asthma[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(5): 667-672.
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