细胞因子信号转导抑制因子与类风湿关节炎的相关性研究进展

doi:10.3969/j.issn.1674-8115.2022.07.015

上海交通大学学报（医学版） ›› 2022, Vol. 42 ›› Issue (7): 945-951.doi: 10.3969/j.issn.1674-8115.2022.07.015

细胞因子信号转导抑制因子与类风湿关节炎的相关性研究进展

雷海桃¹(), 田雪梅²(), 金芳全¹

^1.甘肃中医药大学中医临床学院，兰州 730101
^2.甘肃省中医院风湿骨病中心，兰州 730050

收稿日期:2022-04-04 接受日期:2022-06-14 出版日期:2022-07-28 发布日期:2022-09-04
通讯作者: 田雪梅，电子信箱：2607497237@qq.com。
作者简介:雷海桃（1995—），女，硕士生；电子信箱：2638445200@qq.com。
基金资助:
国家重点研发计划(2018YFC1705203);国家中医药管理局行业专项项目(20150700107);甘肃省卫生健康委员会中医药管理局中医药项目(GZKP-2021-12)

Advances in the correlation between cytokine signal transduction inhibitors and rheumatoid arthritis

LEI Haitao¹(), TIAN Xuemei²(), JIN Fangquan¹

^1.Clinical College of Chinese Medicine, Gansu University of Traditional Medicine, Lanzhou 730101, China
^2.Department of Rheumatology and Orthopedics Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China

Received:2022-04-04 Accepted:2022-06-14 Online:2022-07-28 Published:2022-09-04
Contact: TIAN Xuemei, E-mail: 2607497237@qq.com.
Supported by:
National Key Research and Development Program of China(2018YFC1705203);Industry Special Project of National Administration of Traditional Chinese Medicine(20150700107);TCM Project from Administration of Traditional Chinese Medicine of Gansu Municipal Health Commission(GZKP-2021-12)

摘要/Abstract

摘要：

类风湿关节炎是一种以滑膜炎症、骨质破坏、血管翳形成为特征的慢性对称性疾病。炎症介质与类风湿关节炎的发病机制关系密切，且随着炎症介质水平的升降，类风湿关节炎的严重程度明显受到影响。该文回顾了近年国内外学者对细胞因子信号转导抑制因子与类风湿关节炎的相关性研究，发现作为内源性负性调节因子，细胞因子信号转导抑制因子通过阻断信号转导和转录激活因子（signal transducer and activator of transcription，STAT）的磷酸化、抑制Janus激酶（Janus kinase，JAK）活性，参与细胞内外信号转导，介导Ｔ细胞存活和分化，诱导炎症因子的转录和激活，调控多种细胞因子的产生，对体内多种免疫反应的激活起调控作用。因此，作为抗炎的中介蛋白，细胞因子信号转导抑制因子通过多种途径参与炎症反应，与类风湿关节炎的发生发展密切相关，有望成为该病诊断和预后的生物标志物。同时，该文预测与细胞因子信号转导抑制因子相关的细胞凋亡、免疫调控、软骨代谢及自噬等相关性研究可能成为未来类风湿关节炎的研究热点。进一步深入探究细胞因子信号转导抑制因子与类风湿关节炎的相关性及其机制，可能为治疗类风湿关节炎开拓新视野。

关键词: 类风湿关节炎, 细胞因子信号转导抑制因子, 炎症, JAK/STAT通路, NF-κB通路, MAPK通路

Abstract:

Rheumatoid arthritis (RA) is a chronic symmetrical disease with synovial inflammation, bone destruction and pannus formation. Inflammatory mediators are closely related to the pathogenesis of RA, and the severity of RA is significantly affected by the promotion and demotion of inflammatory mediator levels. In this review, we have reviewed the studies about the correlation between cytokine signaling inhibitory factors and RA in recent years. We have found that cytokine signaling inhibitory factors, as endogenous negative regulators, are involved in intra- and extra-cellular signal transduction, mediating T cell survival and differentiation, inducing transcription and activation of inflammatory factors, and playing a regulatory role in the activation of various immune responses invivovia blocking the phosphorylation of signal transducer and activator of transcription (STAT) and inhibiting the activity of Janus kinase (JAK). Therefore, as an anti-inflammatory mediator protein, cytokine signaling inhibitory factors are involved in inflammatory responses via various pathways, closely related to the occurrence and development of RA, and are expected to be a biomarker for the diagnosis and prognosis for RA. Meanwhile, we predict that the study of apoptosis, immune regulation, cartilage metabolism and autophagy related to cytokine signaling inhibitors may become a research hotspot for RA in the future. Further in-depth research on the correlation and mechanism of cytokine signaling inhibitory factors and RA may widen our vision for the treatment of RA.

Key words: rheumatoid arthritis (RA), suppressor of cytokine signaling (SOCS), inflammation, JAK/STAT signaling pathway, NF-κB signaling pathway, MAPK signaling pathway

中图分类号:

R593.2

雷海桃, 田雪梅, 金芳全. 细胞因子信号转导抑制因子与类风湿关节炎的相关性研究进展[J]. 上海交通大学学报（医学版）, 2022, 42(7): 945-951.

LEI Haitao, TIAN Xuemei, JIN Fangquan. Advances in the correlation between cytokine signal transduction inhibitors and rheumatoid arthritis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(7): 945-951.

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细胞因子信号转导抑制因子与类风湿关节炎的相关性研究进展

Advances in the correlation between cytokine signal transduction inhibitors and rheumatoid arthritis

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