上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2025, Vol. 45 ›› Issue (5): 578-584.doi: 10.3969/j.issn.1674-8115.2025.05.006

• 论著 · 临床研究 • 上一篇    下一篇

不伴糖尿病的高血压患者血清骨诱导因子与肾功能及血压的关系

翟文慧, 黄绮芳(), 陈怡琳, 李晓东, 王继光   

  1. 上海交通大学医学院附属瑞金医院，上海市高血压研究所，上海 200025
  • 收稿日期:2024-09-23 接受日期:2025-02-28 出版日期:2025-05-28 发布日期:2025-05-28
  • 通讯作者: 黄绮芳，副研究员，博士；电子信箱：qifanghuang@163.com。
  • 作者简介:翟文慧（1999—），女，硕士生；电子信箱：2420885978@qq.com。
  • 基金资助:
    国家自然科学基金(81970353);上海市卫生健康委员会临床研究专项基金(202340035)

Serum osteoglycin level in relation to renal function and blood pressure in non-diabetic patients with hypertension

ZHAI Wenhui, HUANG Qifang(), CHEN Yilin, LI Xiaodong, WANG Jiguang   

  1. Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2024-09-23 Accepted:2025-02-28 Online:2025-05-28 Published:2025-05-28
  • Contact: HUANG Qifang, E-mail: qifanghuang@163.com.
  • Supported by:
    National Natural Science Foundation of China(81970353);Foundation of Shanghai Municipal Health Commission(202340035)

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摘要：

目的·探讨不伴糖尿病的高血压患者血清骨诱导因子（osteoglycin，OGN）与肾功能及血压的关系。方法·选择上海交通大学医学院附属瑞金医院高血压科未确诊糖尿病且肾功能下降的高血压患者36例（肾功能下降组）和性别、年龄及诊室血压匹配的肾功能正常者38例（肾功能正常组），用酶联免疫吸附试验检测患者血清OGN浓度，采用慢性肾病流行病学（CKD-EPI）公式计算肾小球滤过率估计值（estimated glomerular filtration rate，eGFR）。比较肾功能下降组与肾功能正常组间血清OGN水平，分析血清OGN水平与eGFR及血压之间的相关性。结果·血清OGN水平在肾功能下降组与肾功能正常组间比较，差异无统计学意义（P=0.708），且与eGFR无显著相关性（P=0.952）。在肾功能下降组中，血清OGN水平的相关因素为平均动脉压、年龄、吸烟（P<0.05）；调整相关因素后，肾功能下降组血清OGN水平与诊室收缩压、诊室舒张压、24 h平均收缩压及24 h平均舒张压均呈独立正相关（P<0.05）。肾功能正常组患者血清OGN水平与血压无显著相关性（P˃0.05）。结论·在不伴糖尿病的高血压患者中，血清OGN水平与eGFR无相关性；在肾功能下降患者中，血清OGN水平升高与较高的诊室收缩压、诊室舒张压、24 h平均收缩压及24 h平均舒张压独立相关。

关键词: 骨诱导因子, 高血压, 肾功能, 动态血压

Abstract:

Objective ·To investigate the association of serum osteoglycin (OGN) levels with renal function and blood pressure in non-diabetic patients with hypertension. Methods ·Hypertensive patients without a diagnosis of diabetes mellitus were recruited from the Hypertension Department of Ruijin Hospital, Shanghai Jiaotong University School of Medicine. A total of 36 renal dysfunction patients (renal dysfunction group) and 38 normal renal function patients (normal renal function group), matched for age, gender and clinic blood pressure, were included in this study. Serum OGN concentrations were measured by the enzyme-linked immunosorbent assay (ELISA). Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The serum OGN levels were compared between the renal dysfunction group and the normal renal function group. The correlations of serum OGN level with eGFR and blood pressure were analyzed. Results ·There was no significant statistical difference in serum OGN levels between the renal dysfunction group and the normal renal function group (P=0.708). Serum OGN levels were not significantly associated with eGFR (P=0.952). In the renal dysfunction group, mean arterial pressure, age and current smoking status were relevant factors of serum OGN levels (P<0.05). After adjustment for confounders, serum OGN levels were independently associated with clinic systolic and diastolic blood pressure, 24-hour ambulatory mean systolic and diastolic blood pressure in the renal dysfunction group (P<0.05), but not in the normal renal function group (P˃0.05). Conclusion ·In non-diabetic patients with hypertension, serum OGN levels are not significantly associated with eGFR. In patients with renal dysfunction, higher serum OGN levels are independently associated with higher clinic systolic blood pressure, clinic diastolic blood pressure, 24-hour ambulatory mean systolic and diastolic blood pressure.

Key words: osteoglycin, hypertension, renal function, ambulatory blood pressure

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