上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (3): 343-.

• 综述 • 上一篇    下一篇

高血压致左室射血分数正常者心力衰竭的发病机制

曹李媛, 史浩颖, 综述；戴秋艳, 审校   

  1. 上海交通大学 第一人民医院心内科, 上海 200080
  • 出版日期:2010-03-25 发布日期:2010-03-24
  • 作者简介:曹李媛（1984—）, 女, 住院医师, 硕士；电子信箱: young_2006198444@yahoo.com.cn。

Mechanisms in heart failure with normal left ventricular ejection fraction caused by hypertension

CAO Li-yuan, SHI Hao-ying, reviewer；DAI Qiu-yan, reviser   

  1. Department of Cardiology, The First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2010-03-25 Published:2010-03-24

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摘要：

高血压是左心室射血分数正常者发生心力衰竭（HFNEF）的主要病因之一。高血压性心脏病一般为进展性心室肥大和纤维化，可导致舒张功能不全和HFNEF。目前对高血压致HFNEF的过程仍未完全明确。文章发主要从心肌细胞自身机制、心肌细胞外神经—内分泌—细胞因子机制及血流动力学机制三方面阐述高血压致HFNEF的发病机制。

关键词: 高血压, 左室射血分数正常的心力衰竭, 发病机制

Abstract:

Hypertension is a major contributor to the development of heart failure with normal left ventricular ejection fraction (HFNEF). Generally, hypertensive heart disease is a process of developing ventricular hypertrophy and fibrosis, which eventually leads to diastolic dysfunction and HFNEF. Now little is known about the process from hypertension to HFNEF, and this article explains the mechanisms from three factors of myocardial mechanisms, neuro-endocrinecytokine mechanisms and hemodynamic mechanisms.

Key words: hypertension, heart failure with normal left ventricular ejection fraction, mechanisms