年龄相关性听力损失研究进展与临床干预策略

doi:10.3969/j.issn.1674-8115.2022.09.004

上海交通大学学报（医学版） ›› 2022, Vol. 42 ›› Issue (9): 1182-1187.doi: 10.3969/j.issn.1674-8115.2022.09.004

• 前沿述评 • 上一篇

年龄相关性听力损失研究进展与临床干预策略

黄治物¹^,²^,³^,⁴(), 吴皓¹^,²^,³^,⁴()

^1.上海交通大学医学院附属第九人民医院耳鼻咽喉头颈外科，上海 200011
^2.上海交通大学医学院耳科学研究所，上海 200125
^3.上海市耳鼻疾病转化医学重点实验室，上海 200125
^4.上海交通大学医学院医学技术学院听觉言语科学系，上海 200025

收稿日期:2022-05-19 接受日期:2022-07-21 出版日期:2022-09-28 发布日期:2022-09-28
通讯作者: 吴皓 E-mail:huangzw086@163.com;wuhao@shsmu.edu.cn
作者简介:黄治物（1965—），男，教授，研究员，博士；电子信箱：huangzw086@163.com。
基金资助:
国家自然科学基金(81730028);上海申康医院发展中心临床三年行动计划(SHDC2020CR1044B);上海交通大学医工交叉研究基金(YG2021ZD14);上海交通大学医疗机器人研究院项目(XK2019015);上海交通大学医学院转化协同创新基金(TM202011)

Research progress and clinical intervention strategy of age-related hearing loss

HUANG Zhiwu¹^,²^,³^,⁴(), WU Hao¹^,²^,³^,⁴()

^1.Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
^2.Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China
^3.Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai 200125, China
^4.Faculty of Hearing and Speech Science, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2022-05-19 Accepted:2022-07-21 Online:2022-09-28 Published:2022-09-28
Contact: WU Hao E-mail:huangzw086@163.com;wuhao@shsmu.edu.cn
Supported by:
National Natural Science Foundation of China(81730028);Clinical Research Three-year Action Plan of Shanghai Hospital Development Center(SHDC2020CR1044B);Medical-Engineering Cross Fund of Shanghai Jiao Tong University(YG2021ZD14);Project of Institute of Medical Robotics of Shanghai Jiao Tong University(XK2019015);Transformation Co-innovation Fund of Shanghai Jiao Tong University School of Medicine(TM202011)

摘要/Abstract

摘要：

年龄相关性听力损失（age-related hearing loss，ARHL），又称老年性聋。长期以来，人们对其危害性认识不足，使得该疾病在全球范围内未受到足够重视。近十年来，随着老龄化的加剧及其相关社会问题的增加，ARHL越来越受到政府和社会的特别关注，其病理机制及临床干预的相关研究也得到了迅猛发展，但迄今为止由遗传因素、环境因素等引起的致病机制仍不明确。基于此，该文简要介绍了ARHL的病理基本特征，综述了其遗传和环境因素（主要是噪声暴露）相关致病机制、临床干预效果的相关研究，以及作者所在课题组在该方面的研究进展，旨在为政府方面制定老年人群听力健康相关干预和医疗政策提供参考。

Abstract:

Age-related hearing loss (ARHL), also known as presbycusis, has not been paid enough attention to worldwide due to the lack of awareness of its harmfulness for a long time. In the past decade, with the increase of aging and related social problems, ARHL has attracted more and more attention from government and society, and its pathological mechanism and clinical intervention research have also developed rapidly. However, it is still unclear about the pathogenic mechanism of ARHL caused by genetic and environmental factors. This review briefly introduces the basic pathological characteristics of ARHL, and summarizes the related researches on its genetic and environmental (especially noise exposure) pathogenic mechanism and clinical intervention effect, as well as the research progress of the writers' research group in this field, which is expected to help government promote and formulate relevant interventions and medical policies on the hearing health in the elderly.

Key words: age-related hearing loss (ARHL), presbycusis, pathogenesis, hearing intervention, cognitive impairment

中图分类号:

R764.43

黄治物, 吴皓. 年龄相关性听力损失研究进展与临床干预策略[J]. 上海交通大学学报（医学版）, 2022, 42(9): 1182-1187.

HUANG Zhiwu, WU Hao. Research progress and clinical intervention strategy of age-related hearing loss[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(9): 1182-1187.

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年龄相关性听力损失研究进展与临床干预策略

Research progress and clinical intervention strategy of age-related hearing loss

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