上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (5): 511-.

• 专题报道（肾上腺疾病） • 上一篇    下一篇

醛固酮与顽固性高血压

张 霞, 综述；王卫庆, 审校   

  1. 上海交通大学 医学院瑞金医院内分泌代谢病科 上海市内分泌代谢病科研究所 上海市内分泌代谢病临床医学中心, 上海 200025
  • 出版日期:2010-05-25 发布日期:2010-05-28
  • 通讯作者: 王卫庆, 电子信箱: wqingw@hotmail.com。
  • 作者简介:张 霞（1983—）, 女, 硕士生；电子信箱: zhangxia010203@126.com。
  • 基金资助:

    上海市科委基金（064119629）

Aldosterone and resistant hypertension

ZHANG Xia, reviewer；WANG Wei-qing, reviser   

  1. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2010-05-25 Published:2010-05-28
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 064119629

PDF (PC)

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摘要：

顽固性高血压是指同时服用包含利尿剂在内的3种不同作用机制的降压药物后，血压仍在目标水平之上，是一种特殊类型的高血压，临床并不少见。醛固酮是人体内最重要、作用最强的盐皮质激素，广泛参与体内各种代谢活动，醛固酮的过多分泌在顽固性高血压的发生发展中起着重要作用。

关键词: 醛固酮, 顽固性高血压, 盐皮质激素受体拮抗剂

Abstract:

Resistant hypertension is defined as blood pressure that remains above goal despite the use of three different antihypertensive medications in effective doses, ideally including a diuretic. It is special and not rare in clinic. Aldosterone, the most important mineralocorticoid, is extensively involved in various metabolic activities. However, aldosterone excess plays an important role in the development of resistant hypertension.

Key words: aldosterone, resistant hypertension, mineralocorticoid receptor antagonist