上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (11): 1352-.doi: 10.3969/j.issn.1674-8115.2010.11.008

• 论著（临床研究） • 上一篇    下一篇

2型糖尿病家系中正常糖耐量一级亲属的胰岛β细胞功能研究

章 明, 胡耀敏, 滕香宇, 陈雅文, 黄 融, 刘 伟   

  1. 上海交通大学 医学院附属仁济医院内分泌科, 上海 200127
  • 出版日期:2010-11-25 发布日期:2010-11-29
  • 通讯作者: 刘 伟, 电子信箱: sue_liuwei@163.com。
  • 作者简介:章 明（1975—）, 男, 主治医师, 硕士生；电子信箱: zmmark@msn.com。
  • 基金资助:

    国家自然科学基金（30670988）和浦东新区社会发展局卫生科技项目（PW2008D-1）

Function change of pancreatic islet β-cells in first degree relatives with normal glucose tolerance in type 2 diabetes mellitus families

ZHANG Ming, HU Yao-min, TENG Xiang-yu, CHEN Ya-wen, HUANG Rong, LIU Wei   

  1. Department of Endocrinology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2010-11-25 Published:2010-11-29
  • Supported by:

    National Natural Science Foundation of China, 30670988；Pudong New Area Social Development Bureau Foundation, PW2008D-1

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摘要：

目的 研究2型糖尿病（T2DM）家系一级亲属中糖耐量正常者胰岛β细胞的功能状况。方法 选择糖耐量正常的2型糖尿病家系一级亲属(T2DM一级亲属组，n=94)和无糖尿病家族史的糖耐量正常者（正常对照组，n=98）作为研究对象。采用口服葡萄糖耐量试验和血清胰岛素释放试验分别测算全身胰岛素敏感性指数[ISI(Matsuda)]及餐后30 min和总体胰岛素释放指数（IGI30和IGI）；进一步推算得到葡萄糖处置指数（DI）,包括DI30[ISI(Matsuda)×IGI30]和DI[ISI(Matsuda)×IGI]，以评估胰岛β细胞胰岛素分泌的早期和总体状况。结果 T2DM一级亲属组和正常对照组的ISI(Matsuda) 分别为107.39±41.88 和105.18±44.18，DI分别为631.04±179.25和665.66±230.71，两组间ISI(Matsuda) 和DI比较差异均无统计学意义（P<0.05）；T2DM一级亲属组DI30显著低于正常对照组，分别为1 248.44±894.41 和1 558.35±1 015.66（P<0.05）。结论 对于T2DM 家系中正常糖耐量的一级亲属个体，在胰岛素敏感性并未降低的情况下，胰岛β细胞已存在早期胰岛素分泌功能缺陷。

关键词: 2型糖尿病, 一级亲属, 口服葡萄糖耐量试验, 胰岛β细胞功能, 胰岛素敏感性

Abstract:

Objective To investigate the function of pancreatic islet β-cells in first degree relatives with normal glucose tolerance in type 2 diabetes mellitus (T2DM) families. Methods The first degree relatives of T2DM families with normal glucose tolerance (T2DM first degree relatives group, n=94) and normal glucose tolerance subjects without diabetes mellitus family history (normal control group, n=98) were enrolled. Oral glucose tolerance test and serum insulin release test were taken for obtaining the whole body insulin sensitivity index [ISI(Matsuda)], early insulinogenic index and total insulinogenic index (IGI30 and IGI), respectively. Glucose disposition indexes (DI) including DI30 [ISI(Matsuda)×IGI30] and DI [ISI(Matsuda)×IGI] were calculated to evaluate the early and total insulin secretion of islet β-cells. Results ISI(Matsuda) in T2DM first degree relatives group and normal control group were 107.39±41.88 and 105.18±44.18, respectively, DI were 631.04±179.25 and 665.66±230.71, respectively, and there was no significant difference in ISI(Matsuda) and DI between these two groups (P>0.05). However, DI30 in first degree relatives group (1 248.44±894.41) was significantly lower than that in normal control group (1 558.35±1 015.66)（P<0.05）. Conclusion There is early insulin secretion deficiency of pancreatic islet β-cells in first degree relatives with normal glucose tolerance in T2DM families, while the insulin sensitivity still remains normal.

Key words: type 2 diabetes mellitus, first degree relative, oral glucose tolerance test, islet β-cell function, insulin sensitivity