上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (12): 1535-.doi: 10.3969/j.issn.1674-8115.2010.12.021

• 论著（临床研究） • 上一篇    下一篇

半纤维素单纯闭合敷料对烧伤或整形手术供皮区创面愈合的促进作用

刘 健, 郑捷新, 施 燕, 张 勤, 廖镇江   

  1. 上海交通大学 医学院附属瑞金医院灼伤整形科, 上海 200025
  • 出版日期:2010-12-25 发布日期:2010-12-31
  • 通讯作者: 郑捷新, 电子信箱: zhengjiexin7@hotmail.com。
  • 作者简介:刘 健（1974—）, 女, 主治医师, 硕士；电子信箱: jennetrj@hotmaill.com。

Efficacy of hemicellulose dressing for wound healing of donor sites of burn or reconstruction

LIU Jian, ZHENG Jie-xin, SHI Yan, ZHANG Qin, LIAO Zhen-jiang   

  1. Department of Burns, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2010-12-25 Published:2010-12-31

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摘要：

目的 评价半纤维素单纯闭合性敷料Veloderm®促进烧伤整形手术刃厚供皮区创面愈合的有效性和安全性。方法 采用随机、开放、阳性药平行对照的试验方法进行研究。将Veloderm®外敷于首次烧伤或整形手术刃厚供皮区创面（试验组，n=24），以临床常用且疗效确定的凡士林油纱布作为阳性药平行对照（对照组, n=24），比较两组创面愈合时间以及手术后第7天的创面愈合百分率、累计痊愈率及总有效率，观察不良反应的发生情况，评价Veloderm®对创面愈合的促进作用以及使用的安全性。结果 试验组和对照组创面愈合时间分别为(6.25±1.11) d和(7.00±0.93) d，两组间差异有统计学意义（P<0.05）。术后第7天，试验组创面愈合百分率、累计痊愈率和总有效率分别为（97.92±5.69）%、87.50%和100%，显著高于对照组的（93.37±8.92）%、58.33%和83.33%，差异均有统计学意义(P<0.05)。两组均无药物相关不良反应发生病例。结论 纤维素单纯闭合性敷料Veloderm®外敷对烧伤或整形手术供皮区创面的愈合具有显著促进作用，且使用安全性良好。

关键词: 半纤维素单纯闭合性敷料, 烧伤, 供皮区, 创面愈合

Abstract:

Objective To investigate the efficacy and safety of hemicellulose dressing Veloderm® for wound healing of donor sites of burn or reconstruction. Methods A randomized, open and controlled clinical trial was conducted. Hemicellulose dressing Veloderm® (test group, n=24) and commonly used Vaseline gauze (positive parallel control)(control group, n=24) were applied to the donor sites of burn or reconstruction, respectively. The time of wound healing, and wound healing rates, cumulative healing rates and total effective rates 7 d after operation were compared between two groups, the adverse effects were observed, and the efficacy and safety of Veloderm® for wound healing were evaluated. Results There was significant difference in the healing time of donor sites between test group and control group [(6.25±1.11) d vs (7.00±0.93）d, P<0.05]. The wound healing rate, cumulative healing rate and total effective rate 7 d after operation in test group were significantly higher than those in control group [(97.92±5.69)% vs (93.37±8.92)%, 87.50% vs 58.33%,100% vs 83.33%; P<0.05 for all]. There was no medicine-related adverse effect in both groups. Conclusion Hemicellulose dressing Veloderm® is effective and safe for wound healing of donor sites of burn or reconstruction.

Key words: hemicellulose dressing, burn, donor site, wound healing