上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (7): 1027-.doi: 10.3969/j.issn.1674-8115.2011.07.035

• 综述 • 上一篇    下一篇

MicroRNA和血液系统肿瘤的基因调控

庄立琨, 童建华   

  1. 上海交通大学 医学院附属瑞金医院 上海血液学研究所, 上海 200025
  • 出版日期:2011-07-28 发布日期:2011-07-27
  • 通讯作者: 童建华, 电子信箱: jhtong@yahoo.com。
  • 作者简介:庄立琨（1987—）, 男, 硕士生；电子信箱: zlk0823@163.com。

MicroRNA and gene regulation in hematopoietic tumors

ZHUANG Li-kun, TONG Jian-hua   

  1. Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2011-07-28 Published:2011-07-27

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摘要：

微小RNA（miRNA）是一类长度为20~25 nt的非编码RNA，广泛存在于真核生物中，通过与由靶基因转录而成的mRNA序列互补结合，在转录后水平调节基因的表达。miRNA参与生命过程中一系列重要进程，包括胚胎早期发育、细胞增殖、凋亡和分化等。miRNA表达水平的异常往往与人类肿瘤的发生密切相关，具有类似于癌基因或抑癌基因的作用。越来越多的研究表明，miRNA在血液系统肿瘤发生发展中起着重要的调控作用，该文将对这一领域的研究进展进行综述。

关键词: 微小RNA, 血液系统肿瘤, 基因调控

Abstract:

MicroRNA (miRNA) is a family of non-coding RNA with 20-25 nt in length, which has a wide distribution in eukaryotes. It can regulate the gene expression at the level of post-transcription by binding to the mRNA. miRNA is involved in a wide range of biological processes, including early embryonic development, cell proliferation, apoptosis and differentiation. Abnormal expression of miRNA usually correlates with various human tumors, acting as oncogenes or tumor suppressors. Increasing studies have indicated that miRNA play an important regulatory role in hematopoietic tumorigenesis, and the research progress in this field is reviewed in this paper.

Key words: microRNA, hematopoietic tumors, gene regulation