上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (8): 1057-.doi: 10.3969/j.issn.1674-8115.2011.08.001

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眼科转化医学研究的现状和展望

范先群, 徐晓芳   

  1. 上海交通大学 医学院附属第九人民医院眼科 上海交通大学 医学院眼科视觉科学研究所, 上海 200011
  • 出版日期:2011-08-28 发布日期:2011-08-29
  • 作者简介:范先群（1964—）, 男, 教授, 博士生导师；电子信箱: fanxq@sh163.net。
  • 基金资助:

    国家自然科学基金（30973279, 81000404）；上海市重点学科建设项目（S30205）

Current situation and prospects of translational medicine in ophthalmology

FAN Xian-qun, XU Xiao-fang   

  1. Department of Ophthalmology, Institute of Ophthalmology and Visual Sciences, the Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
  • Online:2011-08-28 Published:2011-08-29
  • Supported by:

    National Natural Science Founding of China, 30973279, 81000404；Shanghai Leading Academic Discipline Project, S30205

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摘要：

转化医学是基础研究与临床医疗之间双向转化的研究体系，是将临床医疗中发现的问题转化为基础研究方向，然后再将基础科研成果快速转向临床应用，它是一个双向、不断循环向上的永无止境的研究过程。转化医学在眼科的应用发展包括在糖尿病视网膜病变和黄斑变性中的应用、人工角膜和角膜缘干细胞标志物研究、眼眶骨折修复手术中组织工程骨的构建、眼科遗传性疾病的基因定位和眼科新型药物的开发等。眼科转化医学研究尚处于探索阶段，仍有很多问题亟待解决。

关键词: 转化医学, 眼科学, 基础研究

Abstract:

Translational medicine is a two-way research system between basic research and clinical medicine. It converts the problems found in clinic into the directions of basic research, and then quickly promotes the clinical applications of basic scientific research. It is a two-way, cyclic, upward and endless process. Applications of translational medicine in ophthalmology include therapy for diabetic retinopathy and age-related macular degeneration, studies of artificial cornea and corneal stem cell markers, construction of engineering bone tissues in surgical repair of orbital fracture, genic location of genetic eye diseases and development of new drugs. Translational research in ophthalmology is at the exploratory stage, and there are still many issues to be addressed.

Key words: translational medicine, ophthalmology, basic medicine