上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (11): 1612-.doi: 10.3969/j.issn.1674-8115.2011.11.023

• 论著（临床研究） • 上一篇    下一篇

错误监控功能检测方法的建立与应用

陈兴时1, 唐云翔2, 徐一峰3, 王继军4, 张明岛1, 楼翡璎1, 梁建华1, 陈 冲1, 殷光中5, 张载福6   

  1. 1.上海交通大学 |医学院附属精神卫生中心神经生理室, 上海 200030； 2.中国人民解放军第二军医大学医学心理教研室, 上海 200433； 3.上海交通大学 医学院附属精神卫生中心精神科, 上海 200030； 4.上海交通大学 医学院附属精神卫生中心脑电影像室, 上海 200030； 5.苏州广济医院精神科, 苏州 215008； 6.金华市第二医院精神科, 金华 321016
  • 出版日期:2011-11-28 发布日期:2011-11-29
  • 通讯作者: 唐云翔, 电子信箱: tangyunxiang1973@tom.com；徐一峰, 电子信箱: hyyyb@gmail.com。
  • 作者简介:陈兴时（1957-）, 男, 教授；电子信箱: chenxingshi2008@163.com。
  • 基金资助:

    国家自然科学基金（30971046, 30770772）；国家重点基础研究发展计划（“九七三”计划）（2010CB529605）

Creation and application of test methods for error-monitoring function

CHEN Xing-shi1, TANG Yun-xiang2, XU Yi-feng3, WANG Ji-jun4, ZHANG Ming-dao1, LOU Fei-ying1, LIANG Jian-hua1, CHEN Chong1, YIN Guang-zhong5, ZHANG Zai-fu6   

  1. 1.Department of Electrophysiology, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China；2.Department of Medical Psychology, the Second Military Medical University, Shanghai 200433, China；3.Department of Psychiatry, 4.Department of Electronic Encephalography Source Imaging, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China；5.Department of Psychiatry, Suzhou Guangji Hospital, Suzhou 215008, China；6.Department of Psychiatry, Jinhua the Second Hospital, Jinhua 321016, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    National Natural Science Foundation of China, 30971046, 30770772；National Basic Research Program of China, “973” Program, 2010CB529605

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摘要：

目的 利用事件相关脑电位（ERP）技术探讨健康成人错误监控功能的特征。方法 将62名19~50岁的右利手健康成人作为被试者（男性33名，女性29名），平均年龄（29.6±6.6）岁，平均受教育年限（16.7±2.0）年。应用德国Brain Products公司的ERP记录与分析系统检测被试者前额区（Fz）、中央区（Cz）、左中央区（C3）、右中央区（C4）及顶区（Pz）的错误相关负电位（ERN），对ERN潜伏期和波幅进行统计学分析。结果 各脑区头皮记录点均在约50 ms处出现1个负波，ERN波形较稳定。统计学分析结果显示：C3脑区与C4脑区的ERN潜伏期和波幅比较，差异均无统计学意义（P>0.05）；在Fz、Cz、Pz 3个脑区，男性组与女性组的ERN潜伏期和波幅比较，差异也无统计学意义（P>0.05）；Fz和Cz脑区的ERN波幅与被试者年龄呈显著正相关（r=0.282,P=0.027；r=0.250,P=0.049）。结论 健康成人的ERN较稳定、可靠，在神经精神科临床工作中具有一定的推广和应用价值。

关键词: 健康成人, 错误监控机制, 事件相关脑电位, 正常值库

Abstract:

Objective To investigate the features of error-monitoring function in healthy adults with event-related potentials (ERP). Methods Sixty-two righthanded healthy adults (33 males and 29 females) aged between 19 and 50 years were enrolled, with the mean age of (29.6±6.6) years and mean education experience of (16.7±2.0) years. Error-related negativity (ERN) in frontal zone (Fz), central zone (Cz), left central zone (C3), right central zone (C4) and parietal zone (Pz) was detected with ERP instrument (Brain Products, Germany), and the latencies and wave amplitudes of ERN were statistically analysed. Results A negative wave was detected in each scalp electrode about 50 ms after the stimuli presented, and the ERN waveform was stable. Statistical analysis revealed that there was no significant difference in the latencies and wave amplitudes of ERN between C3 and C4 (P>0.05). In Fz, Cz and Pz, there was no significant difference in the latencies and wave amplitudes of ERN between males and females (P>0.05). The wave amplitudes of ERN in Fz and Cz were significantly positively related to the age of subjects (r=0.282, P=0.027; r=0.250, P=0.049). Conclusion ERN is stable and reliable in healthy adults. As a clinically valuable ERP component, ERN can be used in clinical practice of department of Neurology and Psychiatry.

Key words: healthy adult, error-monitoring mechanism, event-related potentials, normal value bank