›› 2012, Vol. 32 ›› Issue (4): 405-.doi: 10.3969/j.issn.1674-8115.2012.04.007

• 专题报道(排尿功能障碍及盆底重建) • 上一篇    下一篇

不同温度条件下碱化利多卡因联合肝素膀胱灌注治疗膀胱疼痛综合征的临床疗效分析

冷 静, 陈慧兴, 吕坚伟, 李冬玲, 李佳怡, 薄隽杰, 刘东明, 黄翼然   

  1. 上海交通大学 医学院附属仁济医院泌尿外科 上海交通大学尿失禁及盆底重建诊治中心, 上海 200001
  • 出版日期:2012-04-28 发布日期:2012-04-27
  • 通讯作者: 黄翼然, 电子信箱: huangyiran@126.com。
  • 作者简介:冷 静(1966—), 男, 副教授, 硕士;电子信箱: lengjing88@hotmail.com。

Clinical efficacy of bladder irrigation with heparin and alkalinized lidocaine for painful bladder syndrome under different temperatures

LENG Jing, CHEN Hui-xing, LV Jian-wei, LI Dong-ling, LI Jia-yi, BO Jun-jie, LIU Dong-ming, HUANG Yi-ran   

  1. Department of Urology, Renji Hospital, Center of Urinary Incontinence and Pelvic Reconstruction, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China
  • Online:2012-04-28 Published:2012-04-27

摘要:

目的 比较两种温度条件下(常温、高温)碱化利多卡因联合肝素膀胱灌注治疗膀胱疼痛综合征(PBS)的临床疗效。方法 收集诊断为PBS的女性新发病例62例。治疗前应用O´Leary-sant问卷进行问题评分(ICPI)和症状评分(ICSI)。将患者按随机、单盲的原则分成常温组和高温组,常温组采用常温(20 ℃~24 ℃)碱化利多卡因联合肝素膀胱灌注治疗;高温组采用高温(37 ℃~40 ℃)碱化利多卡因联合肝素膀胱灌注治疗;8周与16周治疗结束时再次应用O´Leary-sant问卷进行ICPI和ICSI。结果 两组治疗前后ICPI和ICSI均有明显改善,差异有统计学意义(P<0.05)。治疗后8周,高温组ICPI和ICSI较常温组有明显改善,差异有统计学意义(P<0.05);治疗后16周,高温组ICPI和ICSI较常温组有进一步的改善,差异具有统计学意义(P<0.001)。高温组中3例(9.38%)首次灌注后出现膀胱区灼热不适感,经数次灌注后可耐受;常温组无不良事件发生。结论 高温条件下碱化利多卡因联合肝素膀胱灌注治疗PBS的临床疗效优于常温条件下的膀胱灌注,短期内无不良事件发生。

关键词: 膀胱疼痛综合征, 膀胱灌注, 温度

Abstract:

Objective To compare the clinical efficacy of bladder irrigation with heparin and alkalinized lidocaine for painful bladder syndrome (PBS) under two different temperature (normal temperature and high temperature). Methods Sixty-two female patients newly-diagnosed with PBS were collected. The Interstitial Cystitis Problem Index (ICPI) and Interstitial Cystitis Symptom Index (ICSI) were obtained with O´Leary-sant questionnaire before treatment. Patients were randomly divided into normal temperature group (bladder irrigation with heparin and alkalinized lidocaine under 20 ℃-24 ℃) and high temperature group (bladder irrigation with heparin and alkalinized lidocaine under 37 ℃-40 ℃). ICPI and ICSI were obtained again with O´Leary-sant questionnaire after 8 weeks and 16 weeks of treatment. Results ICPI and ICSI were significantly improved after treatment in two groups (P<0.05). Compared with normal temperature group, ICPI and ICSI in high temperature group were significantly improved 8 weeks after treatment (P<0.05) and 16 weeks after treatment (P<0.001). Three patients (9.38%) in high temperature group experienced strong burning sensation in bladder after first irrigation, but they tolerated after a few times of irrigation. There was no adverse event in normal temperature group. Conclusion The clinical efficacy of bladder irrigation with heparin and alkalinized lidocaine for PBS under high temperature is better than that under normal temperature, with no short-term adverse event.

Key words: painful bladder syndrome, bladder irrigation, temperature