上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (7): 907-.doi: 10.3969/j.issn.1674-8115.2012.07.018

• 论著（基础研究） • 上一篇    下一篇

聚氨酯复合材料抗菌性能的实验研究

朱 锐, 孔方圆, 肖家祈, 郑元俐   

  1. 上海交通大学 医学院附属第九人民医院口腔修复科 |上海市口腔医学重点实验室, 上海 200011
  • 出版日期:2012-07-28 发布日期:2012-08-17
  • 通讯作者: 郑元俐, 电子信箱: zhengyuanli@yahoo.com。
  • 作者简介:朱 锐（1986—）, 女, 硕士生；电子信箱: sharp_zhu@163.com。
  • 基金资助:

    上海市科委基金（09411954700）

Study of antibiotic property of polyurethane based soft liner material

ZHU Rui, KONG Fang-yuan, XIAO Jia-qi, ZHENG Yuan-li   

  1. Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, the Ninth People´s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
  • Online:2012-07-28 Published:2012-08-17
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 09411954700

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摘要：

目的 研究含聚膦腈纳米球的聚氨酯基复合软衬材料的抗菌性能。方法 分别以含1%、5%聚膦腈纳米球的聚氨酯基复合材料（1%PSZ组和5%PSZ组）、纯聚氨酯（PU组）、自固化型硅橡胶软衬材料（阴性对照组）和灭菌平皿的内平板（空白对照组）进行试件制备，每组30个。测试各组试件对白假丝酵母菌、金黄色葡萄球菌和大肠杆菌的抗菌性能。采用贴膜培养法对菌落进行培养计数，并计算抗菌率。判定抗菌率低于90%的材料无抗菌性能。结果 在PU组、1%PSZ组和5%PSZ组试件对白假丝酵母菌的抗菌率分别为5.60%、3.75%和6.25%，对金黄色葡萄球菌的抗菌率分别为－2.31%、1.63%和12.80%，对大肠杆菌的抗菌率分别为8.65%、0.75%和6.02%。结论 添加5%以内聚膦腈纳米球的聚氨酯基复合软衬材料对口腔菌群平衡无明显影响。

关键词: 聚氨酯, 聚膦腈纳米球, 抗菌性能, 软衬

Abstract:

Objective To investigate the antibacterial property of polyurethane based material containing polyphosphazenes nanosphere. Methods Test specimens made of polyurethane (PU group), polyurethane containing 1% polyphosphazenes nanosphere (1% PSZ group), polyurethane containing 5% polyphosphazenes nanosphere (5% PSZ group), selfcuring silicon rubber material (negative group) and inner flat of sterilized plate (blank control group) were prepared (n=30). The antibacterial property for Candida albicans, Staphylococcus aureus and Escherichia coli of test specimens in each group was tested. The colonies were counted by sticking membrane culture method, and the antibacterial rates were calculated. Material with antibacterial rate lower than 90% was regarded as having no antibacterial property. Results The antibacterial rates of test specimens in PU group, 1% PSZ group and 5% PSZ group for Candida albicans were 5.60%, 3.75% and 6.25% respectively, those for Staphylococcus aureus were －2.31%, 1.63% and 12.80% respectively, and those for Escherichia coli were 8.65%, 0.75% and 6.02% respectively. Conclusion Polyurethane based soft liner materials containing less than 5% polyphosphazenes nanosphere have no significant effect on oral microflora balance.

Key words: polyurethane, polyphosphazenes, antibacterial property, soft liner material