上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (8): 1121-.doi: 10.3969/j.issn.1674-8115.2011.08.017

• 论著（基础研究） • 上一篇    下一篇

聚氨酯复合材料表面白色假丝酵母菌黏附的实验研究

郑元俐, 李 静, 孔方圆   

  1. 上海交通大学 医学院附属第九人民医院口腔修复科 上海市口腔医学重点实验室, 上海 200011
  • 出版日期:2011-08-28 发布日期:2011-08-29
  • 作者简介:郑元俐（1964—）, 女, 主任医师, 博士, 硕士生导师；电子信箱: zhengyuanli@yahoo.com。
  • 基金资助:

    上海市科委基金（0941195470）

Study of Candida albicans adhesion to polyurethane composites

ZHENG Yuan-li, LI Jing, KONG Fang-yuan   

  1. Department of Prosthodontics, Shanghai Key Laboratory of Stomatology, the Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
  • Online:2011-08-28 Published:2011-08-29
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 0941195470

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摘要：

目的 分析含纳米聚磷腈的聚氨酯材料表面白色假丝酵母菌的黏附情况。方法 制备含1%、5%纳米聚磷腈的聚氨酯材料试件（PZS-1%、PZS-5%组，n=12）和硅橡胶软衬材料试件（硅橡胶组，n=12），各组试件分别行白色假丝酵母菌黏附实验，光学显微镜下观察试件表面白色假丝酵母菌黏附情况，菌落形成单位计数法测定各组白色假丝酵母菌黏附量（×104 CFU/mL）。结果 PZS-1%、PZS-5%和硅橡胶组试件表面的白色假丝酵母菌黏附量分别为207.800±22.300、133.200±31.597和200.600±32.250。统计学分析结果表明：PZS-5%组试件表面的白色假丝酵母菌黏附量显著低于PZS-1%组和硅橡胶组，差异均有统计学意义（P<0.001），而PZS-1%组与硅橡胶组试件表面白色假丝酵母菌黏附量比较差异无统计学意义（P>0.05）。结论 与PZS-1%和硅橡胶软衬材料相比，PZS-5%材料表面黏附的白色假丝酵母菌明显减少。聚磷腈成分的添加可能影响材料表面白色假丝酵母菌的黏附能力。

关键词: 聚氨酯, 聚磷腈, 软衬, 白色假丝酵母菌, 黏附

Abstract:

Objective To investigate the Candida albicans adhesion to polyurethane composites containing nano-polyphosphazene. Methods Specimens of polyurethane composites containing 1% polyphosphazene (PZS-1% group, n=12) and 5% polyphosphazene (PZS-5% group, n=12) and specimens of silicone rubber-based soft lining material (silicone rubber group, n=12) were prepared. Candida albicans adhesion tests were performed in each group of specimens. The adhesion of Candida albicans to specimens was observed under light microscope, and colony forming unit counting was conducted to determine the amount of Candida albicans adhesion in each group (×104 CFU/mL). Results The amount of Candida albicans adhesion to specimens in PZS-1% group, PZS-5% group and silicone rubber group was 207.800±22.300, 133.200±31.597 and 200.600±32.250 respectively. It was revealed by statistical analysis that the amount of Candida albicans adhesion to specimens in PZS-5% group was significantly lower than that in PZS-1% group and silicone rubber group (P<0.001), while there was no significant difference between PZS-1% group and silicone rubber group (P>0.05). Conclusion The amount of Candida albicans adhesion to PZS-5% is significantly lower than that adhesion to PZS-1% and silicone rubber-based soft lining material. The supplement of polyphosphazene in polyurethane composites may have an effect on Candida albicans adhesion.

Key words: polyurethane, polyphosphazene, soft lining, Candida albicans, adhesion