上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (10): 1347-.doi: 10.3969/j.issn.1674-8115.2012.10.015

• 论著（临床研究） • 上一篇    下一篇

白癜风患者焦虑状态与血清β-内啡肽水平的关系

臧运书1, 纪晓丽2   

  1. 1.青岛大学医学院附属医院皮肤科, 青岛 266003； 2.北京延庆县医院皮肤科, 北京 102100
  • 出版日期:2012-10-28 发布日期:2012-11-05
  • 作者简介:臧运书（1963—）, 男, 副教授, 硕士；电子信箱: 13573233611@139.com。

Relationship between anxiety and serum β-endorphin in patients with vitiligo

ZANG Yun-shu1, JI Xiao-li2   

  1. 1.Department of Dermatology, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China； 2.Department of Dermatology, Beijing Yanqing County Hospital, Beijing 102100, China
  • Online:2012-10-28 Published:2012-11-05

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摘要：

目的 探讨白癜风患者焦虑情绪与血清β-内啡肽水平的关系。方法 选择80例进展期白癜风患者（病例组）和40例健康体检者（对照组）为研究对象，采用ZUNG焦虑自评量表（SAS）进行焦虑情绪评分，应用酶联免疫吸附法（ELISA）测定血清β-内啡肽水平。结果 病例组SAS评分（50.85±12.23）显著高于对照组（37.86±11.23）（t=5.63，P＜0.01)。病例组焦虑发生率（47.5%, 38/80）显著高于对照组（5.0%， 2/40）（χ2=21.67，P＜0.01)。在病例组中，对于SAS评分和焦虑发生率，女性患者高于男性患者，未婚患者高于已婚患者，皮肤损伤发生于暴露部位的患者高于发生于非暴露部位的患者，16～24岁的患者高于25岁以上的患者，差异均有统计学意义（P＜0.05或P＜0.01）；病程≤6个月的患者与病程>6个月的患者SAS评分和焦虑发生率比较，有高等学历的患者与无高等学历的患者SAS评分和焦虑发生率比较，差异均无统计学意义（P＞0.05)。病例组患者血清β-内啡肽质量浓度为（219.11±30.18）ng/L，显著高于对照组[（162.16±19.65）ng/L]（t=9.12，P＜0.01)。病例组中，有焦虑症状的患者血清β-内啡肽质量浓度为（241.71±31.76）ng/L，显著高于无焦虑症状的患者[（197.91±23.29）ng/L]（t=8.66，P＜0.01)。结论 白癜风患者可能存在焦虑情绪，且患者血清中β-内啡肽水平可能与白癜风及焦虑情绪有关。

关键词: 白癜风, 焦虑, β-内啡肽

Abstract:

Objective To investigate the relationship between anxiety and serum β-endorphin in patients with vitiligo. Methods Eighty patients with developing vitiligo (case group) and 40 healthy controls (control group) were selected. ZUNG self-rating anxiety scale (SAS) was employed to determine the anxiety status, and enzyme linked immunosorbent assay (ELISA) was adopted to measure the serum β-endorphin levels. Results The SAS scores in case group （50.85±12.23）was significantly higher than that in control group （37.86±11.23）(t=5.63，P＜0.01). The prevalence of anxiety in case group (47.5%, 38/80) was significantly higher than that in control group (5.0%，2/40）（χ2=21.67，P＜0.01). In case group, the SAS score and prevalence of anxiety of females were significantly higher than those of males; the SAS score and prevalence of anxiety of the unmarried were significantly higher than those of the married; the SAS score and prevalence of anxiety in patients with vitiligo in exposed skin were significantly higher than those in non-exposed skin; and the SAS score and prevalence of anxiety in patients aged between 16 and 24 were significantly higher than those aged more than 25 (P＜0.05 or P＜0.01). There was no significant difference in SAS score and prevalence of anxiety between patients with disease duration ≤6 months and those with disease duration >6 months and between patients with higher education and those without higher education （P＞0.05). The mass concentration of serum β-endorphin in case group was （219.11±30.18）ng/L, which was significantly higher than that in control group [（162.16±19.65）ng/L] （t=9.12，P＜0.01). In case group, the mass concentration of serum β-endorphin in patients with anxiety was （241.71±31.76）ng/L, which was significantly higher than that in patients without anxiety [（197.91±23.29）ng/L]（t=8.66，P＜0.01). Conclusion Patients with vitiligo may be affected by anxiety, and the serum β-endorphin levels may be associated with vitiligo and anxiety.

Key words: vitiligo, anxiety, β-endorphin