›› 2012, Vol. 32 ›› Issue (12): 1646-.doi: 10.3969/j.issn.1674-8115.2012.12.026

• Review • Previous Articles     Next Articles

Research progress of microRNA in diagnosis, treatment and prognosis evaluation for pancreatic ductal adenocarcinoma

ZHANG Jun-feng, HUA Rong   

  1. Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2012-12-28 Published:2012-12-31
  • Supported by:

    Shanghai Health Bureau Foundation, 2011213


MicroRNA (miRNA) are a class of short noncoding RNAs, with 17-25 nucleotides in length, which play a role in the regulation of gene expression at posttranscriptional level. Recent studies have revealed that miRNA may be associated with pathogenesis, progression, invasion and metastasis of tumors. Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer which is characterized by the absence of biomarkers for early diagnosis and effective strategies for therapeutic intervention. The current status of miRNA in diagnosis, treatment and prognosis evaluation for PDAC is introduced in this paper.

Key words: pancreatic ductal adenocarcinoma, microRNA, tumor biomarker, diagnosis