›› 2013, Vol. 33 ›› Issue (5): 607-.doi: 10.3969/j.issn.1674-8115.2013.05.020

• Original article (Basic research) • Previous Articles     Next Articles

Effect of Ganoderma lucidum polysaccharides on hyperthyroidism and liver injury in Graves´|disease mice model

ZHAO Ze-fei1, ZHAO Yong-ju2, GU Ming-jun1, CUI Jiu-lan3, WANG Shu4   

  1. 1.Department of Endocrine and Metabolic Diseases, Gongli Hospital, Shanghai 200135, China； 2.Department of Geriatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China； 3.Shanghai Institute of Endocrinology and Metabolism, Shanghai 200025, China； 4.Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2013-05-28 Published:2013-05-28
  • Supported by:

    Shanghai Municipal Health Bureau Foundation, 2010Y054；Shanghai Pudong New District Health Bureau Foundation, PW2010B-3； Shanghai Pudong New District Health System Excellent Young Medical Talent Project, PWRq2010-02

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Abstract:

Objective To investigate the effect of Ganoderma lucidum polysaccharides on hyperthyroidism and liver injury in the mice model of Graves´ disease (GD). Methods GD mice model was constructed by immunizing BALB/c mice with thyroid stimulating hormone receptor-A (TSHR-A). Serum thyroxine (T4), thyroid stimulating hormone receptor antibody (TRAb), and liver function parameters were measured, and correlation analysis was performed. The mice were intragastrically managed with pure water, low-dose Ganoderma lucidum polysaccharides (100 mg·kg-1·d-1) and high-dose Ganoderma lucidum polysaccharides (400 mg·kg-1·d-1) respectively, and the change of serum T4, TRAb, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were determined. Results Serum ALT, AST and ALP in mice with hyperthyroidism in model group were significantly higher than those in mice without hyperthyroidism in model group and mice in control group (P<0.05). Serum AST and ALP were positively significantly related to serum T4(r=0.585, P<0.05; r=0.744, P<0.05), but were not related to serum TRAb (P>0.05). Serum T4 and TRAb in model mice were not significantly changed after treatment with Ganoderma lucidum polysaccharides (P>0.05). Serum ALT and ALP in mice with hyperthyroidism in model group treated with low-dose Ganoderma lucidum polysaccharides were significantly superior to those in pure water group (P<0.05). Conclusion Ganoderma lucidum polysaccharides may not work on hyperthyroidism improvement in GD mice model, but can improve the liver injury caused by hyperthyroidism.

Key words: Graves´, disease, Ganoderma lucidum polysaccharides, hyperthyroidism, liver injury