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Effects of glucagon-like peptide-1 receptor agonist on glucose and lipid metabolism and function of intestinal L cells in type 2 diabetic rats

SUI Chun-hua1, WU Hui2, XIA Fang-zhen1, ZHAI Hua-ling1, LU Ying-li1   

  1. 1.Department of Endocrinology, the Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China； 2.Department of Endocrinology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China
  • Online:2013-12-28 Published:2014-01-02

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Abstract:

Objective To study the effects of glucagon-like peptide-1 (GLP-1) receptor agonist on GLP-1 expression in intestinal L cells of type 2 diabetic rats. Methods The changes of body weight, fasting glucose, lipid profile, fasting insulin, insulin resistance index, and insulin sensitivity index were observed in normal rats (normal group), diabetic rats (diabetic group), and diabetic rats treated with GLP-1 receptor agonist (Exenatide treated group). Expressions of GLP-1 in intestinal L cells were determined by immunohistochemical method. Results Compared to diabetic group, body weight, fasting glucose, lipid profiles, fasting insulin, lipid profile, and insulin resistance index significantly improved in Exenatide treated group (P<0.05). Compared to normal group, expressions of GLP-1 were significantly lower both in diabetic group and Exenatide treated group (P<0.01, P<0.05), whereas the expression of GLP-1 of Exenatide treated group was higher than that of diabetic group (P<0.05). Conclusion GLP-1 receptor agonist may improve GLP-1 expression in intestinal L cells in type 2 diabetic rats.

Key words: glucagon-like peptide-1 receptor agonist, L cell, diabetes mellitus