Abstract:

Objective To detect the distribution and expression of IL-17 in the gingival tissue of patients with different types of periodontitis and to preliminary explore the possible effects of IL-17 on the occurrence and development of periodontitis. Methods Gingival biopsies were divided into the control group (n=10), chronic periodontitis group (n=10), and aggressive periodontitis group(n=10). The distribution and expression of IL-17 in the gingival tissue of each group were detected by the immunohistochemistry. Results IL-17 expressed in the gingival epithelium and connective tissue full layer. The expressions of IL-17 in the gingival tissue of the chronic periodontitis group and aggressive periodontitis group were significantly higher than that of the control group (P<0.01). The expressions of IL-17 in the gingival epithelium and connective tissue of the aggressive periodontitis group were significantly higher than those of the chronic periodontitis group (P<0.01). Conclusion IL-17 involves in the occurrence and development of periodontal inflammation. The expressions of IL-17 in the gingival tissue of patients with different types of periodontitis are different.

Key words: interleukin-17, chronic periodontitis, aggressive periodontitis, gingival