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Research progresses of effects of placental growth factor on myocardial regeneration treatment after acute myocardial infarction

ZHANG Wen-tian, LIAN Feng, XUE Song   

  1. Department of Cardiovascular Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2014-10-28 Published:2014-10-28
  • Supported by:

    Foundation of Science and Technology Commission of Shanghai Municipality, 12NM0502100; Foundation of Shanghai Municipal Education Committee, 11YZ48,13ZZ091


Hypoxic condition of myocardial cells will stimulate myocardial cells and interstitial cells to release growth factors to induce angiogenesis and cardiac remodeling after acute myocardial infarction (AMI). Placental growth factor (PlGF) is a stress product after the injury of myocardial tissue. It can not only promote angiogenesis and regulate the inflammatory response, but also closely related to ventricular remodeling and paracrine mechanism of stem cells. This paper reviews the effects of PlGF on the myocardial regeneration treatment after AMI.

Key words: placenta growth factor, acute myocardial infarction, angiogenesis, cardiac remodeling, paracrine