Journal of Shanghai Jiao Tong University (Medical Science) ›› 2023, Vol. 43 ›› Issue (6): 673-679.doi: 10.3969/j.issn.1674-8115.2023.06.003
• Pediatric asthma column • Previous Articles
LI Pengyun1(), DAI Yinfang1, LU Yanhong1, YU Xingmei1, XU Lina1, DI Wujianfeng2, HAO Chuangli1()
Received:
2023-02-28
Accepted:
2023-06-01
Online:
2023-06-28
Published:
2023-06-28
Contact:
HAO Chuangli
E-mail:1214215251@qq.com;hcl_md@163.com
Supported by:
CLC Number:
LI Pengyun, DAI Yinfang, LU Yanhong, YU Xingmei, XU Lina, DI Wujianfeng, HAO Chuangli. Clinical study of exhaled nitric oxide in children with asthma and allergic rhinitis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(6): 673-679.
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URL: https://xuebao.shsmu.edu.cn/EN/10.3969/j.issn.1674-8115.2023.06.003
Item | Acute exacerbation stage (n=33) | Chronic persistent stage (n=32) | Clinical remission stage (n=34) | H/χ2 | P value |
---|---|---|---|---|---|
Age/year | 7.48±2.43 | 8.31±3.48 | 6.50 (5.00, 9.00) | 1.329 | 0.514 |
Gender (male/female)/n(%) | 24 (72.7)/9 (27.3) | 24 (75.0)/8 (25.0) | 21 (61.8)/13 (38.2) | 1.582 | 0.453 |
Height/cm | 129.00 (115.00, 139.50) | 134.16±20.34 | 125.00 (117.75, 134.88) | 1.369 | 0.504 |
Weight/kg | 26.00 (20.50, 32.00) | 28.00 (19.25, 43.00) | 24.50 (21.00, 30.50) | 0.475 | 0.789 |
Different severity of rhinitis/n(%) | 9.644 | 0.047 | |||
Intermittent mild | 10 (30.3) | 14 (43.8) | 21 (61.8) | ||
Persistent mild | 11 (33.3) | 13 (40.6) | 8 (23.5) | ||
Persistent moderate-to-severe | 12 (36.4) | 5 (15.6) | 5 (14.7) |
Tab 1 Comparison of basic information
Item | Acute exacerbation stage (n=33) | Chronic persistent stage (n=32) | Clinical remission stage (n=34) | H/χ2 | P value |
---|---|---|---|---|---|
Age/year | 7.48±2.43 | 8.31±3.48 | 6.50 (5.00, 9.00) | 1.329 | 0.514 |
Gender (male/female)/n(%) | 24 (72.7)/9 (27.3) | 24 (75.0)/8 (25.0) | 21 (61.8)/13 (38.2) | 1.582 | 0.453 |
Height/cm | 129.00 (115.00, 139.50) | 134.16±20.34 | 125.00 (117.75, 134.88) | 1.369 | 0.504 |
Weight/kg | 26.00 (20.50, 32.00) | 28.00 (19.25, 43.00) | 24.50 (21.00, 30.50) | 0.475 | 0.789 |
Different severity of rhinitis/n(%) | 9.644 | 0.047 | |||
Intermittent mild | 10 (30.3) | 14 (43.8) | 21 (61.8) | ||
Persistent mild | 11 (33.3) | 13 (40.6) | 8 (23.5) | ||
Persistent moderate-to-severe | 12 (36.4) | 5 (15.6) | 5 (14.7) |
Item | Acute exacerbation stage (n=33) | Chronic persistent stage (n=32) | Clinical remission stage (n=34) | H/F | P value |
---|---|---|---|---|---|
EOS proportion/% | 3.97±2.80 | 5.42±2.69 | 3.55 (2.13, 5.88) | 5.437 | 0.066 |
EOS count/(×109·L-1) | 3.40 (1.95, 5.45) | 0.42±0.20 | 0.29 (0.19, 0.48) | 1.916 | 0.384 |
FeNO/ppb | 45.00 (31.50, 56.00)①② | 27.00 (13.25, 45.75)③ | 12.50 (9.00, 17.25) | 38.861 | 0.000 |
FnNO/ppb | 664.03±244.13④ | 573.22±261.69 | 516.29±224.41 | 3.128 | 0.048 |
Tab 2 Comparison of EOS, FeNO and FnNO among children in different stages of asthma
Item | Acute exacerbation stage (n=33) | Chronic persistent stage (n=32) | Clinical remission stage (n=34) | H/F | P value |
---|---|---|---|---|---|
EOS proportion/% | 3.97±2.80 | 5.42±2.69 | 3.55 (2.13, 5.88) | 5.437 | 0.066 |
EOS count/(×109·L-1) | 3.40 (1.95, 5.45) | 0.42±0.20 | 0.29 (0.19, 0.48) | 1.916 | 0.384 |
FeNO/ppb | 45.00 (31.50, 56.00)①② | 27.00 (13.25, 45.75)③ | 12.50 (9.00, 17.25) | 38.861 | 0.000 |
FnNO/ppb | 664.03±244.13④ | 573.22±261.69 | 516.29±224.41 | 3.128 | 0.048 |
Item | Different severities of rhinitis | F value | P value | ||
---|---|---|---|---|---|
Intermittent mild (n=45) | Persistent mild (n=32) | Persistent moderate-to-severe (n=22) | |||
Different stages of asthma | |||||
Acute exacerbation stage (n=33) | 596.70±211.16 | 614.27±243.68 | 765.75±255.02 | 1.725 | 0.195 |
Chronic persistent stage (n=32) | 373.86±190.12① | 678.77±171.15② | 857.00±222.23③ | 15.709 | 0.000 |
Clinical remission stage (n=34) | 405.05±140.56④ | 693.38±287.44⑤ | 700.20±46.19⑥ | 10.730 | 0.000 |
F value | 5.510 | 0.347 | 0.643 | ||
P value | 0.008 | 0.710 | 0.537 |
Tab 3 Comparisons of FnNO in different severities of rhinitis among different stages of asthma
Item | Different severities of rhinitis | F value | P value | ||
---|---|---|---|---|---|
Intermittent mild (n=45) | Persistent mild (n=32) | Persistent moderate-to-severe (n=22) | |||
Different stages of asthma | |||||
Acute exacerbation stage (n=33) | 596.70±211.16 | 614.27±243.68 | 765.75±255.02 | 1.725 | 0.195 |
Chronic persistent stage (n=32) | 373.86±190.12① | 678.77±171.15② | 857.00±222.23③ | 15.709 | 0.000 |
Clinical remission stage (n=34) | 405.05±140.56④ | 693.38±287.44⑤ | 700.20±46.19⑥ | 10.730 | 0.000 |
F value | 5.510 | 0.347 | 0.643 | ||
P value | 0.008 | 0.710 | 0.537 |
Item | Acute exacerbation stage | Chronic persistent stage | Clinical remission stage | |||
---|---|---|---|---|---|---|
r value | P value | r value | P value | r value | P value | |
FEV1/pred/% | -0.393 | 0.024 | -0.451 | 0.010 | -0.321 | 0.064 |
FVC/pred/% | -0.477 | 0.005 | -0.279 | 0.122 | -0.184 | 0.298 |
FEV1/FVC/pred/% | -0.015 | 0.936 | -0.308 | 0.086 | -0.324 | 0.061 |
PEF/pred/% | -0.367 | 0.036 | -0.050 | 0.786 | 0.065 | 0.714 |
MEF75/pred/% | -0.154 | 0.392 | -0.197 | 0.279 | -0.304 | 0.081 |
MEF50/pred/% | -0.323 | 0.066 | -0.329 | 0.066 | -0.261 | 0.135 |
MEF25/pred/% | -0.243 | 0.174 | -0.320 | 0.074 | -0.095 | 0.592 |
MMEF75/25/pred/% | -0.358 | 0.041 | -0.266 | 0.141 | -0.248 | 0.158 |
Tab 4 Correlation analysis between lung function indicators and FeNO in children with different stages of asthma
Item | Acute exacerbation stage | Chronic persistent stage | Clinical remission stage | |||
---|---|---|---|---|---|---|
r value | P value | r value | P value | r value | P value | |
FEV1/pred/% | -0.393 | 0.024 | -0.451 | 0.010 | -0.321 | 0.064 |
FVC/pred/% | -0.477 | 0.005 | -0.279 | 0.122 | -0.184 | 0.298 |
FEV1/FVC/pred/% | -0.015 | 0.936 | -0.308 | 0.086 | -0.324 | 0.061 |
PEF/pred/% | -0.367 | 0.036 | -0.050 | 0.786 | 0.065 | 0.714 |
MEF75/pred/% | -0.154 | 0.392 | -0.197 | 0.279 | -0.304 | 0.081 |
MEF50/pred/% | -0.323 | 0.066 | -0.329 | 0.066 | -0.261 | 0.135 |
MEF25/pred/% | -0.243 | 0.174 | -0.320 | 0.074 | -0.095 | 0.592 |
MMEF75/25/pred/% | -0.358 | 0.041 | -0.266 | 0.141 | -0.248 | 0.158 |
Item | Acute exacerbation stage | Chronic persistent stage | Clinical remission stage | ||||
---|---|---|---|---|---|---|---|
r value | P value | r value | P value | r value | P value | ||
FEV1/pred/% | -0.378 | 0.030 | -0.291 | 0.107 | -0.043 | 0.809 | |
FVC/pred/% | -0.422 | 0.014 | -0.01 | 0.957 | 0.073 | 0.682 | |
FEV1/FVC/pred/% | -0.063 | 0.729 | -0.144 | 0.431 | -0.149 | 0.402 | |
PEF/pred/% | -0.421 | 0.015 | -0.063 | 0.731 | 0.117 | 0.509 | |
MEF75/pred/% | -0.041 | 0.819 | -0.208 | 0.254 | -0.176 | 0.318 | |
MEF50/pred/% | -0.215 | 0.230 | -0.096 | 0.602 | -0.102 | 0.567 | |
MEF25/pred/% | -0.104 | 0.564 | -0.064 | 0.729 | -0.019 | 0.913 | |
MMEF75/25/pred/% | -0.194 | 0.278 | -0.119 | 0.516 | -0.058 | 0.747 |
Tab 5 Correlation analysis between lung function indicators and FnNO in children with different stages of asthma
Item | Acute exacerbation stage | Chronic persistent stage | Clinical remission stage | ||||
---|---|---|---|---|---|---|---|
r value | P value | r value | P value | r value | P value | ||
FEV1/pred/% | -0.378 | 0.030 | -0.291 | 0.107 | -0.043 | 0.809 | |
FVC/pred/% | -0.422 | 0.014 | -0.01 | 0.957 | 0.073 | 0.682 | |
FEV1/FVC/pred/% | -0.063 | 0.729 | -0.144 | 0.431 | -0.149 | 0.402 | |
PEF/pred/% | -0.421 | 0.015 | -0.063 | 0.731 | 0.117 | 0.509 | |
MEF75/pred/% | -0.041 | 0.819 | -0.208 | 0.254 | -0.176 | 0.318 | |
MEF50/pred/% | -0.215 | 0.230 | -0.096 | 0.602 | -0.102 | 0.567 | |
MEF25/pred/% | -0.104 | 0.564 | -0.064 | 0.729 | -0.019 | 0.913 | |
MMEF75/25/pred/% | -0.194 | 0.278 | -0.119 | 0.516 | -0.058 | 0.747 |
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