Abstract:

Objective To explore the effects of iodinated contrast media on therapeutic effect of ¹³¹I in patients with pulmonary metastases from differentiated thyroid carcinoma. Methods The clinical data of 82 patients with pulmonary metastases from differentiated thyroid carcinoma were collected, and were classified into three groups according to the conduction of contrast CT scan: contrast CT scan group 1(<3 months of the interval between ¹³¹I treatment and contrast CT scan, n=32), contrast CT scan group 2 (≥3 months of the interval between ¹³¹I treatment and contrast CT scan, n=27) and negative control group (without contrast CT scan, n=23). After ¹³¹I treatment, the condition of iodine intake of pulmonary metastatic lesions in each group was observed and analysed by ¹³¹I scan, and the therapeutic effect was evaluated. Results The positive rate of iodine intake of pulmonary metastatic lesions revealed by ¹³¹I scan in contrast CT scan group 1 was significantly lower than those of contrast CT scan group 2 and negative control group（P<0.05）, while there was no significant difference between contrast CT scan group 2 and negative control group（P>0.05）. There was no significant difference in therapeutic effect of ¹³¹I treatment among three groups （P>0.05）. However, the therapeutic effect of patients with negative results in initial ¹³¹I treatment was poorer than those with positive results. Conclusion ¹³¹I scan may predict the therapeutic effect of ¹³¹I treatment in patients with pulmonary metastases from differentiated thyroid carcinoma, and the application of iodinated contrast media within 3 months before ¹³¹I treatment may affect the iodine intake of pulmonary metastatic lesions.

Key words: iodinated contrast media, thyroid carcinoma, pulmonary metastasis, radioactive iodine