Abstract:

Objective To investigate the relationship between fasting blood glucose (FBG) and short-term and long-term outcomes of patients with primary acute myocardial infarction. Methods Six hundred and sixty-eight patients with primary acute myocardial infarction were divided into diabetes mellitus group (n=177), high FBG group (n=351) and normal FBG group (n=140) on the basis of history of diabetes mellitus and FBG level on the next day after admission.The incidences of short-term cardiovascular events and mortality during follow-up in each group were recorded, and the related factors were statistically analysed. Results Logistic and Cox regression analysis revealed that FBG was independent risk factor for long-term death (OR=1.043, P=0.004) and short-term events of malignant arrhythmia (OR=1.106, P=0.001), congestive heart failure (OR=1.060, P=0.037), cardiac shock (OR=1.084, P=0.018) and cardiac death (OR=1.068, P=0.028). Cox regression analysis indicated that the mortality risks of FBG>8.52 mmol/L in high FBG group and FBG>10.65 mmol/L in diabetes mellitus group were three times of that of normal FBG group (HR=3.087, P=0.007; HR=3.456, P=0.002). Conclusion FBG is independent risk factor for short-term cardiovascular events and long-term mortality in patients with primary acute myocardial infarction.

Key words: fasting blood glucose, myocardial infarction, cardiovascular event, mortality