›› 2010, Vol. 30 ›› Issue (7): 856-.

• Review • Previous Articles     Next Articles

Research progress on pathogenesis-related genes and diagnosis and treatment of Kallmann syndrome

SHA Yan-wei, LI Peng, reviewer；LI Zheng, reviser   

  1. Department of Urology, Shanghai Institute of Andrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China
  • Online:2010-07-25 Published:2010-07-26
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 08410701700

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Abstract:

Kallmann syndrome (KS) is a genetically and clinically heterogeneous disease, which is characterised by hypogonadotropic hypogonadism complicated with anosmia. Up till now, five pathogenesisrelated genes of fibroblast growth factor receptor 1(FGFR1), fibroblast growth factor 8 (FGF8), prokineticin receptor 2 gene (PROKR2), prokineticin 2 gene (PROK2) and KAL1 have been identified. The research progress on biological activity, function and phenotype-genotype correlations of Kallmann syndrome related proteins is reviewed in this paper, and the diagnosis and treatment of Kallmann syndrome are also introduced.

Key words: Kallmann syndrome, gene, diagnosis, treatment