›› 2012, Vol. 32 ›› Issue (10): 1334-.doi: 10.3969/j.issn.1674-8115.2012.10.012

• Original article (Clinical research) • Previous Articles     Next Articles

Study on visual P300 evoked by facial expression stimulus in patients with depression

ZHU Yi, CHEN Xing-shi, QIU Jian-yin   

  1. Department of Psychosomatic Medicine, Shanghai Mental Health Center, Shang Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2012-10-28 Published:2012-11-05
  • Supported by:

    Shanghai Mental Health Center Foundation, 08-24

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Abstract:

Objective To investigate the changes of visual P300 evoked by facial expression stimulus in patients with depression. Methods Thirty patients with depression (depression group) and 30 normal controls (control group) were enrolled, and were evaluated by self-designed demographic questionnaire and Hamilton depression scale (HAMD). Besides, the examinations of visual P300 evoked by five facial expression stimulus, including depression, happiness, surprise, anger and disgust were conducted, and were compared between two groups. The correlation analysis of HAMD score with visual P300 was performed in depression group. Results The target P3 latency evoked by depression facial expression was (447.23±26.90) ms, that evoked by happiness facial expression was (444.40±28.52) ms, and both were significantly longer than those of control group (P<0.05). The HAMD score was not correlated with visual P300 evoked by facial expression stimulus in depression group (P＞0.05). Conclusion There are abnormal changes of visual P300 evoked by facial expression stimulus in patients with depression.

Key words: depression, facial expression stimulus, visual P300