›› 2012, Vol. 32 ›› Issue (12): 1641-.doi: 10.3969/j.issn.1674-8115.2012.12.025

• Review • Previous Articles     Next Articles

Roles of histone deacetylase inhibitors in treatment of diabetes mellitus

CHEN Xuan1,2, LI Hua-ping1   

  1. 1.Department of Obstetrics and Gynecology, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China;2.Soochow University School of Medicine, Suzhou 215006, China
  • Online:2012-12-28 Published:2012-12-31
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 12ZR1422200


The prevalence of diabetes mellitus is increasing year by year, and there is an imperative need for more safe, inexpensive and effective drugs for diabetes mellitus. Histone deacetylase inhibitors (HDACi) exhibit promising properties, which can promote pancreatic islet β cell function, prevent β cells from inflammatory damage, improve insulin resistance, regulate immune system balance, improve the metabolism, and positively affect diabetic complications. HDACi may become novel drugs for the prevention and treatment of diabetes mellitus, even for gestational diabetes mellitus. The roles of HDACi in the treatment of diabetes mellitus are reviewed in this paper.

Key words: histone deacetylase inhibitors, diabetes mellitus, insulin, treatment